{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:47:54Z","timestamp":1777481274353,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T00:00:00Z","timestamp":1644105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","award":["Grant No. 2019\u2010333"],"award-info":[{"award-number":["Grant No. 2019\u2010333"]}],"id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lymphomas of the nasal cavity and paranasal sinuses (NPS) are rare. Knowledge on sinonasal B\u2010cell lymphoma (SNBCL) primarily comes from case series or single\u2010center studies on small cohorts. We sought to determine the subtype distribution, clinical characteristics, disease behavior, and prognosis on a nationwide scale, with an emphasis on prognostic factors for the most common sinonasal lymphoma, primary sinonasal diffuse large B\u2010cell lymphoma (PSDLBCL). We collated all data from medical records and national databases on patients registered with SNBCL from 1980 through 2018 in the national pathology registry and collected all tissue samples for validation of diagnosis. We included 205 patients and found 10 different subtypes of lymphoma. Diffuse large B\u2010cell lymphoma (DLBCL) was the predominant subtype (80%). The incidence of SNBCL was 0.14\/100,000 person\u2010years. The five\u2010year progression\u2010free survival (PFS) and overall survival rates for PSDLBCL were 50% and 56%, respectively. For PSDLBCL, Rituximab showed a statistically significant effect (Hazard Ratio 0.22,\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.001), whereas consolidative radiotherapy combined with immunochemotherapy was of limited value (PFS,\n                    <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                    0.93). When treatment failure occurred, DLBCL showed a distinct pattern of recurrence\/dissemination to the NPS, skin, breast, central nervous system (CNS), and\/or testis. Collectively, DLBCL comprised a clear majority of SNBCLs, although nine other subtypes were represented. Data showed that immunochemotherapy increased survival for PSDLBCL and that the addition of radiotherapy did not benefit patients. Furthermore, treatment failure for sinonasal DLBCL showed a possible common pathogenesis with primary extranodal lymphomas of specific locations (e.g., CNS, skin, breast, and testis).\n                  <\/jats:p>","DOI":"10.1002\/hon.2968","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T17:27:51Z","timestamp":1643736471000},"page":"160-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sinonasal B\u2010cell lymphomas: A nationwide cohort study, with an emphasis on the prognosis and the recurrence pattern of primary diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-5514","authenticated-orcid":false,"given":"Patrick R. G.","family":"Eriksen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery\u00a0&amp; Audiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Clasen\u2010Linde","sequence":"additional","affiliation":[{"name":"Hematopathology Section, Department of Pathology Rigshospitalet  Kobenhavn Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-4086","authenticated-orcid":false,"given":"Peter de","family":"Nully Brown","sequence":"additional","affiliation":[{"name":"Department of Hematology Rigshospitalet University of Copenhagen  Kobenhavn Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8715-2749","authenticated-orcid":false,"given":"Laura","family":"Haunstrup","sequence":"additional","affiliation":[{"name":"Department of Hematology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Christoffersen","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-8578","authenticated-orcid":false,"given":"Peter","family":"Asdahl","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels M\u00f8ller","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Holstebro Central Hospital  Holstebro Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1674-160X","authenticated-orcid":false,"given":"Cecilie Dupont","family":"Harwood","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery\u00a0&amp; Audiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-7670","authenticated-orcid":false,"given":"Steffen","family":"Heegaard","sequence":"additional","affiliation":[{"name":"Eye Pathology Section, Department of Pathology Rigshospitalet University of Copenhagen  Kobenhavn Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-8129","authenticated-orcid":false,"given":"Christian von","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery\u00a0&amp; Audiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869709100731"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200302000-00002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950315)75:6<1281::AID-CNCR2820750610>3.0.CO;2-I"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/LMKH083QCXFUUIGS"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.044"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm471"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030403"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.5896"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.03.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26452"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399958"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S99470"},{"key":"e_1_2_9_15_1","volume-title":"WHO 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