{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:58:03Z","timestamp":1792425483334,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Idiopathic multicentric Castleman disease (iMCD) is a polyclonal lymphoproliferative disorder characterized by constitutional symptoms, generalized lymphadenopathy, cytopenias, and multi\u2010organ dysfunction due to excessive cytokines, notably Interleukin\u20106. Idiopathic multicentric Castleman disease is often sub\u2010classified into iMCD\u2010TAFRO, which is associated with thrombocytopenia (T), anasarca (A), fever\/elevated C\u2010reactive protein (F), renal dysfunction (R), and organomegaly (O), and iMCD not otherwise specified (iMCD\u2010NOS), which is typically associated with thrombocytosis and hypergammaglobulinemia. The diagnosis of iMCD is challenging as consensus clinico\u2010pathological diagnostic criteria were only recently established and include several non\u2010specific lymph node histopathological features. Identification of further clinico\u2010pathological features commonly found in iMCD could contribute to more accurate and timely diagnoses. We set out to characterize bone marrow (BM) histopathological features in iMCD, assess differences between iMCD\u2010TAFRO and iMCD\u2010NOS, and determine if these findings are specific to iMCD. Examination of BM specimens from 24 iMCD patients revealed a high proportion with hypercellularity, megakaryocytic atypia, reticulin fibrosis, and plasmacytosis across patients with both iMCD\u2010NOS and iMCD\u2010TAFRO with significantly more megakaryocytic hyperplasia (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001) in the iMCD\u2010TAFRO cases. These findings were also consistent with BM findings from 185 published cases of iMCD\u2010NOS and iMCD\u2010TAFRO. However, these findings are relatively nonspecific as they can be seen in various other infectious, malignant, and autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1002\/hon.2969","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T14:59:48Z","timestamp":1643727588000},"page":"191-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bone marrow findings of idiopathic Multicentric Castleman disease: A histopathologic analysis and systematic literature review"],"prefix":"10.1002","volume":"40","author":[{"given":"Elizaveta","family":"Belyaeva","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Tulane University  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Rubenstein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Cytokine Storm Treatment\u00a0&amp; Laboratory University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3736-1411","authenticated-orcid":false,"given":"Sheila K.","family":"Pierson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Cytokine Storm Treatment\u00a0&amp; Laboratory University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaney","family":"Dalldorf","sequence":"additional","affiliation":[{"name":"Castleman Disease Collaborative Network  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6919-868X","authenticated-orcid":false,"given":"Dale","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0415-2867","authenticated-orcid":false,"given":"Megan S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-8184","authenticated-orcid":false,"given":"David C.","family":"Fajgenbaum","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Cytokine Storm Treatment\u00a0&amp; 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