{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:15:16Z","timestamp":1782828916010,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The advent of chimeric antigen receptor (CAR) T\u2010cell therapy has changed the therapeutic landscape of relapsed\/refractory aggressive B\u2010cell lymphomas. Cytokine release syndrome and immune effector cell\u2010associated neurotoxicity syndrome (ICANS) are the typical adverse events associated with this therapy. Cardiovascular toxicities have also been reported in this setting. However, there is scarce data regarding the development of sinus bradycardia after CAR T\u2010cell therapy. Here, we detail the clinical course of 4 patients with aggressive B\u2010cell malignancies who received CAR T\u2010cells and developed transient and reversible sinus bradycardia in the context of ICANS. We also discuss several hypotheses behind the pathophysiology of this potential new adverse event.<\/jats:p>","DOI":"10.1002\/hon.2976","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T18:18:47Z","timestamp":1644430727000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurotoxicity\u2010associated sinus bradycardia after chimeric antigen receptor T\u2010cell therapy"],"prefix":"10.1002","volume":"40","author":[{"given":"Eva","family":"Catal\u00e1","sequence":"first","affiliation":[{"name":"Department of Hematology Vall d\u2019Hebron University Hospital, Experimental Hematology, Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron Barcelona Hospital Campus  Barcelona 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