{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:02Z","timestamp":1786977842780,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26461418, 17K09924"],"award-info":[{"award-number":["26461418, 17K09924"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To elucidate the long\u2010term outcomes of non\u2010anthracycline\u2010containing therapies and central nervous system (CNS) events in patients with extranodal NK\/T\u2010cell lymphoma, nasal type (ENKTL), the clinical data of 313 patients with ENKTL diagnosed between 2000 and 2013 in a nationwide retrospective study in Japan were updated and analyzed. At a median follow\u2010up of 8.4\u00a0years, the 5\u2010year overall survival (OS) and progression\u2010free survival (PFS) were 71% and 64%, respectively, in 140 localized ENKTL patients who received radiotherapy\u2010dexamethasone, etoposide, ifosfamide, and carboplatin (RT\u2010DeVIC) in clinical practice. Nine (6.4%) patients experienced second malignancies. In 155 localized ENKTL patients treated with RT\u2010DeVIC, 10 (6.5%) experienced CNS relapse (median, 12.8\u00a0months after diagnosis). In five of them, the events were confined to the CNS. Nine of the 10 patients who experienced CNS relapse died within 1\u00a0year after CNS relapse. Multivariate analysis identified gingival (hazard ratio [HR], 54.35; 95% confidence interval [CI], 8.60\u2013343.35) and paranasal involvement (HR, 7.42; 95% CI, 1.78\u201330.89) as independent risk factors for CNS relapse. In 80 advanced ENKTL patients, 18 received steroid (dexamethasone), methotrexate, ifosfamide, L\u2010asparaginase, and etoposide (SMILE) chemotherapy as first\u2010line treatment. Patients who received SMILE as their first\u2010line treatment tended to have better OS than those who did not (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.071). Six (7.5%) advanced ENKTL patients experienced isolated CNS relapse (median, 2.6\u00a0months after diagnosis) and died within 4\u00a0months of relapse. No second malignancies were documented in advanced ENKTL patients. In the entire cohort, the median OS after first relapse or progression was 4.6\u00a0months. 12 patients who survived 5\u00a0years after PFS events were disease\u2010free at the last follow\u2010up. Of those, 11 (92%) underwent hematopoietic stem cell transplantation. Our 8\u2010year follow\u2010up revealed the long\u2010term efficacy and safety of RT\u2010DeVIC and SMILE. The risk of CNS relapse is an important consideration in advanced ENKTL.\n                  <\/jats:p>","DOI":"10.1002\/hon.2977","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T07:10:39Z","timestamp":1644477039000},"page":"667-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term outcomes and central nervous system relapse in extranodal natural killer\/T\u2010cell lymphoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Kana","family":"Miyazaki","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Shimane University Hospital  Izumo 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Kurashiki Center Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Kubota","sequence":"additional","affiliation":[{"name":"Division of Hematology Saitama Cancer Center  Ina Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Terui","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Hematology Saitama Medical University  Moroyama 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Hematology and Medical Oncology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kameoka","sequence":"additional","affiliation":[{"name":"Department of Hematology Akita University  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Oncology Center Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilseung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hematology National Hospital Organization Kyushu Cancer Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Masaki","sequence":"additional","affiliation":[{"name":"Division of Hematology and Immunology Kanazawa Medical University  Ishikawa 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