{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:49:38Z","timestamp":1783547378304,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute lymphoblastic leukemia (ALL) is the most common cancer during childhood, and some high\u2010risk patients with ALL require hematopoietic stem cell transplantation (HSCT). Mainly due to small patient numbers, studies focusing specifically on children and adolescents with T\u2010cell ALL (T\u2010ALL) are limited. Using a nationwide registry, we retrospectively analyzed data from patients under 20\u00a0years old who underwent their first HSCT for T\u2010ALL between 2000 and 2018. As a result, total 484 patients were included, and their median follow\u2010up period was 6.9\u00a0years after HSCT for survivors. While patients receiving HSCT at first complete remission (CR) showed relatively good 5\u2010year leukemia free survival (5yLFS, 73.5%), once relapse occurred, their prognosis was much worse (44.4%) even if they attained second remission again (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Among patients receiving HSCT at CR1, grade II\u2013IV acute graft versus host disease was associated with worse overall and LFS than grade 0\u2013I (5yLFS 69.5% vs. 82.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.026) mainly due to high non\u2010relapse mortality. Among those patients, patients receiving related bone marrow transplantation, unrelated bone marrow transplantation, or unrelated cord blood transplantation showed similar survival (5yLFS, 73.2%, 76.3%, and 77.0%, respectively). For patients undergoing cord blood transplantation at CR1, total\u2010body irradiation\u2010based myeloablative conditioning was associated with better 5yLFS than other conditioning regimens (85.4% vs. 62.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.044), as it reduced the risk of relapse. These results indicate that relapsed patients have much less chance of cure, and that identifying patients who require HSCT for cure and offering them HSCT with optimal settings during CR1 are crucial for children and adolescents with T\u2010ALL.\n                  <\/jats:p>","DOI":"10.1002\/hon.2980","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T21:13:58Z","timestamp":1645737238000},"page":"457-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic factors of children and adolescents with T\u2010cell acute lymphoblastic leukemia after allogeneic transplantation"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-8403","authenticated-orcid":false,"given":"Hisashi","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Pediatrics Okayama University Hospital  Okayama 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Hospital Organization Kyushu Cancer Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Ibaraki Children's Hospital  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Saitama Children's Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Kanagawa Children's Medical Center  Yokohama 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