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However, results of cohort studies and meta\u2010analyses have indicated that the degree of humoral response to SARS\u2010CoV\u20102 vaccines in patients with chronic lymphocytic leukemia (CLL) appears to be lower than that observed in the general population. These inadequate responses are mainly related to the disease itself and to the immunosuppressive effect of therapies administered. In the specific context of CLL, enrolling patients with sub\u2010optimal vaccine\u2010response in pivotal vaccine trials could be considered as an appropriate approach to improve response to the COVID\u201019 vaccine. These clinical trials should also address the issues of regularity and timing of vaccine booster doses or re\u2010vaccinations, especially in patients undergoing therapy with pathway\u2010targeting agents and anti\u2010CD20 monoclonal antibodies. However, since hypogammaglobulinemia is a serious consequence of CLL, patients who do not have a detectable antibody response should be natural candidates for preventive antibody therapy.<\/jats:p>","DOI":"10.1002\/hon.2990","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T22:48:07Z","timestamp":1647643687000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Current perspectives regarding SARS\u2010CoV\u20102 vaccination in\u00a0chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-6507","authenticated-orcid":false,"given":"Stefano","family":"Molica","sequence":"first","affiliation":[{"name":"Department of Hematology Hull University Teaching Hospitals NHS Trust  Hull 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