{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:34:31Z","timestamp":1775079271806,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770213"],"award-info":[{"award-number":["81770213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["19JCYBJC26500 and 18JCZDJC45100"],"award-info":[{"award-number":["19JCYBJC26500 and 18JCZDJC45100"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The mantle cell lymphoma (MCL) International Prognostic Index (MIPI) and combined MIPI (MIPI\u2010c) are commonly used for risk classification of MCL patients. However, these indexes lack immune\u2010related parameters. The purpose of this study was to develop a novel prognostic model that integrated clinical and immune parameters. A total of 189 patients with newly diagnosed MCL from January 2010 to June 2020 were enrolled in our study. A nomogram and immune\u2010related prognostic index (IRPI) were established to predict the overall survival (OS) of patients according to univariate and multivariate analyses. Discrimination and calibration were used to compare the prognostic performance of the IRPI, MIPI, and MIPI\u2010c. External validation was performed based on validation dataset (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0150) from two other centers. The results for the training dataset indicated that B symptoms, platelet count, B2M level, CD4+ T\u2010cell count&lt;26.7% and CD8+ T\u2010cell count&gt;44.2% were predictors for OS. All the prognostic factors were integrated into the nomogram. For the overlap of confidence intervals of each variable, we assigned one point for each factor. The IRPI categorized patients into three risk categories: a score of zero indicated low risk, a score of one or two indicated intermediate risk, and a score of \u22653 indicated high risk. The IRPI showed better discrimination and calibration power than the MIPI and MIPI\u2010c in the training dataset and validation dataset. The novel IRPI is a refined risk stratification index and reflects the strong complementary prognostic effects between clinical and immune parameters in MCL.\n                  <\/jats:p>","DOI":"10.1002\/hon.2994","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:14:21Z","timestamp":1648970061000},"page":"343-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A novel clinical immune\u2010related prognostic model predicts the overall survival of mantle cell lymphoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Huijuan","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"},{"name":"Department of Medical Oncology The Fourth People's Hospital of Jinan  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0066-1234","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinni","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengzi","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongli","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Pathology Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiubao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Immunology\/Biotherapy Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehui","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5447-3282","authenticated-orcid":false,"given":"Qingqing","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Sun Yat\u2010sen 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Stratification of Patients with Burkitt Lymphoma Using Serum Beta2\u2010Microglobulin Levels","author":"Kim HD","year":"2020"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2019.54.4.285"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2188"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016180"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6281-1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27441"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1700244"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2019.1598678"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.2994","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:22:11Z","timestamp":1692789731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,15]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/hon.2994"],"URL":"https:\/\/doi.org\/10.1002\/hon.2994","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.2994\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2994\/v2\/review1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,15]]},"assertion":[{"value":"2021-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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