{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:26:16Z","timestamp":1787495176134,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In symptomatic Waldenstr\u00f6m macroglobulinemia (sWM) patients, prognosis is assessed with the international prognostic scoring system (IPSSWM). In follicular lymphoma and other B\u2010cell and T\u2010cell lymphomas, disease progression within 24\u00a0months (POD24) or (in patients without POD24) after 24\u00a0months has been proposed as the start date for stratifying subsequent survival. In the present report, we assessed in a large series of 472 sWM patients, the prognostic value of this new dynamic endpoint already reported in many other lymphomas subtypes. The 3\u00a0year subsequent survival for patients with POD24 was 75% and 93% for patients without POD24. In sWM patients, departure from the proportional hazards assumption complicated this analysis. In patients without POD24, the median subsequent progression\u2010free survival time of 43\u00a0months accounted for favorable outcome, whereas survival after progression was not influenced by the time to progression. In addition, sensitivity analysis showed that the baseline IPSSWM score also influenced survival after POD24. In sWM patients, we conclude that the apparent difference in survival after POD24 or the 24\u00a0months time\u2010point (in patients without POD24) is mainly explained by the prolonged subsequent progression free survival of latter patients. Indeed, the mortality after progression is not influenced by the time to this event.<\/jats:p>","DOI":"10.1002\/hon.2996","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T18:44:10Z","timestamp":1649270650000},"page":"400-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does early disease progression predict survival after first line\u2010treatment of Waldenstr\u00f6m macroglobulinemia?"],"prefix":"10.1002","volume":"40","author":[{"given":"Julien","family":"Labreuche","sequence":"first","affiliation":[{"name":"Universite de Lille CHU Lille ULR 2694\u2010METRICS: \u00e9valuation des technologies de sant\u00e9 et des pratiques m\u00e9dicales  Lille France"},{"name":"Departement de Biostatistique CHU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Assouan","sequence":"additional","affiliation":[{"name":"Service 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