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However, despite the outstanding efficacy, a high relapse rate is still found in some B\u2010cell malignancies after anti\u2010CD19 CAR T\u2010cell therapy, which emerges as a main barrier for improving the overall response and long\u2010term outcomes. Understanding the resistance mechanism is crucial to improve current CAR T products, better incorporate them into the current therapy system and develop novel CAR approaches. Herein, we discuss the latest advances in understanding the mechanisms limiting efficacy of CAR T\u2010cell therapy, resulting in CD19 negative (CD19\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and CD19 positive (CD19\n                    <jats:sup>+<\/jats:sup>\n                    ) relapses. We also provide a whole scenario of current potential strategies to overcome these barriers.\n                  <\/jats:p>","DOI":"10.1002\/hon.3036","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T14:03:15Z","timestamp":1653919395000},"page":"821-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Overcoming resistance to anti\u2010CD19 CAR T\u2010cell therapy in B\u2010cell malignancies"],"prefix":"10.1002","volume":"40","author":[{"given":"Xingcheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Immunotherapy Research Center for Hematologic Diseases of Hubei Province  Wuhan Hubei 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