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The improved sensitivity of MRD measurements has been paralleled by the development of more effective therapeutic strategies for CLL, increasing the applicability of MRD detection in this setting. Chemotherapy and chemoimmunotherapy have firstly demonstrated their ability to obtain a deep MRD. Combined targeted therapies are also demonstrating a high molecular response rate and prospective trials are exploring the role of MRD to guide the duration of treatment in this setting. In this review we briefly summarize what we have learned about MRD with emphasis on its flow cytometric detection.<\/jats:p>","DOI":"10.1002\/hon.3037","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T16:58:15Z","timestamp":1654534695000},"page":"835-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Flow cytometric evaluation of measurable residual disease in chronic lymphocytic leukemia: Where do we stand?"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-7287","authenticated-orcid":false,"given":"Giovanni","family":"D\u2019Arena","sequence":"first","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit IRCCS Centro di Riferimento Oncologico della Basilicata  Rionero in Vulture 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