{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:22Z","timestamp":1772118622024,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Adult T\u2010cell leukemia\/lymphoma (ATL) patients have a very poor prognosis. The humanized anti\u2010CCR4 therapeutic monoclonal antibody, mogamulizumab, is a key agent for ATL treatment. Our previous integrated molecular analysis demonstrated that among all the driver genes in ATL,\n                    <jats:italic>CCR7<\/jats:italic>\n                    gene alterations were significantly associated with clinical response to mogamulizumab. Accordingly, here we investigated the detailed clinical impact of\n                    <jats:italic>CCR7<\/jats:italic>\n                    alterations in a larger cohort of ATL patients. These\n                    <jats:italic>CCR7<\/jats:italic>\n                    alterations, most of which lead to C\u2010terminus truncations, were observed in 27 of 223 patients (12%). For patients receiving mogamulizumab but not allogeneic hematopoietic stem cell transplantation (HSCT),\n                    <jats:italic>CCR7<\/jats:italic>\n                    alterations were significantly associated with worse survival (median survival from the first dose of mogamulizumab of 0.7\u00a0years for 12 patients with\n                    <jats:italic>CCR7<\/jats:italic>\n                    alterations vs. 1.6\u00a0years for 72 patients without,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.020). On the other hand, the presence or absence of\n                    <jats:italic>CCR7<\/jats:italic>\n                    alterations had no significant impact on survival in the entire cohort (median overall survival of 1.4 and 1.8\u00a0years, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.901), or on the survival of patients receiving allogeneic HSCT (median survival from the day of transplantation of 0.9\u00a0years for 6 patients with\n                    <jats:italic>CCR7<\/jats:italic>\n                    alterations and 1.4\u00a0years for 48 without,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.543). Multivariate analysis indicated that patients with\n                    <jats:italic>CCR4<\/jats:italic>\n                    alterations but lacking\n                    <jats:italic>CCR7<\/jats:italic>\n                    alterations (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020) had significantly better survival after receiving mogamulizumab\u2010containing treatments (hazard ratio for survival, 0.437, 95% confidence interval, 0.192\u20130.994). This study contributes to the establishment of precision medicine for ATL.\n                  <\/jats:p>","DOI":"10.1002\/hon.3072","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T05:50:01Z","timestamp":1661925001000},"page":"876-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>CCR7<\/i>\n                    alterations associated with inferior outcome of adult T\u2010cell leukemia\/lymphoma under mogamulizumab treatment"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-4862","authenticated-orcid":false,"given":"Yuma","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Graduate School of Medical Sciences Nagoya City University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-0777","authenticated-orcid":false,"given":"Takashi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Immunology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Graduate School of Medical Sciences Nagoya City University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Murase","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Graduate School of Medical Sciences Nagoya City University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of Hematology Oita Prefectural Hospital  Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5251-5258","authenticated-orcid":false,"given":"Reiji","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Hematology National Hospital Organization Kyushu Medical Center  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medical Sciences Nagoya City University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kusumoto","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medical Sciences Nagoya City University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-7616","authenticated-orcid":false,"given":"Nobuaki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura General Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-9006","authenticated-orcid":false,"given":"Masahito","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura General Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yonekura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Imamura General Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukie","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Pathology Imamura General Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medical Sciences Nagoya City University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-406X","authenticated-orcid":false,"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura General Hospital  Kagoshima 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