{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:43:46Z","timestamp":1780778626343,"version":"3.54.1"},"reference-count":121,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600168"],"award-info":[{"award-number":["81600168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702082"],"award-info":[{"award-number":["81702082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thrombocytopenia, anasarca, fever, reticulin fibrosis\/renal failure, and organomegaly (TAFRO) syndrome is rare in clinical practice. It is a systemic inflammatory disease caused by a cytokine storm. Its clinical manifestations include thrombocytopenia, systemic edema, fever, bone marrow fibrosis, renal insufficiency, and organ enlargement. The high mortality rate of TAFRO syndrome is due to the difficulty of acquiring biopsy samples for diagnosis and the rapid disease progression. This disease is poorly understood by clinicians. Early detection, accurate diagnosis, and timely treatment play key roles in prolonging the survival of the patients. This review summarizes the latest progress in the pathogenesis, diagnostic criteria, and treatment regimens of TAFRO syndrome, aiming to help clinicians better understand TAFRO syndrome and improve its diagnosis and treatment.<\/jats:p>","DOI":"10.1002\/hon.3075","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T05:13:23Z","timestamp":1663910003000},"page":"310-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["TAFRO syndrome: A disease that known is half cured"],"prefix":"10.1002","volume":"41","author":[{"given":"Tingting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Clinical Medical College Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Clinical Medical College Jinan University  Shenzhen Guangdong China"},{"name":"Department of Hematology Shenzhen People's Hospital  Shenzhen Guangdong China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Clinical Medical College Jinan University  Shenzhen Guangdong China"},{"name":"Department of Hematology Shenzhen People's Hospital  Shenzhen Guangdong China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-192X","authenticated-orcid":false,"given":"Jihao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Clinical Medical College Jinan University  Shenzhen Guangdong China"},{"name":"Department of Hematology Shenzhen People's Hospital  Shenzhen Guangdong China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"issue":"23","key":"e_1_2_11_2_1","first-page":"1001","article-title":"Case records of the Massachusetts general hospital: case No. 40231","volume":"250","author":"Castleman B","year":"1954","journal-title":"N Engl J Med"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003607"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23831"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201010\u2010746933"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896908315812"},{"issue":"5","key":"e_1_2_11_7_1","first-page":"320","article-title":"Thrombocytopenia with mild bone marrow fibrosis accompanied by fever, pleural effusion, ascites and hepatosplenomegaly","volume":"51","author":"Takai K","year":"2010","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0212"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25554"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26292"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2020.05.000440"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010021\u201003159\u2010x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.19021"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000791\u20101"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800906779010227"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2012.10.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005361"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135031"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002792"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000317\u20107"},{"key":"e_1_2_11_21_1","article-title":"Upstream regulators of phosphoinositide 3\u2010kinase and their role in diseases","author":"Wang D","year":"2019","journal-title":"J Cell Physiol"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m116.753236"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.861"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.09.009"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.09.003"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573409915666190902142524"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090971"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102020\u2010137338"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25123"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010020\u201003008\u20103"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010020\u201004275\u20100"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.02.006"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42316"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.152563"},{"key":"e_1_2_11_35_1","article-title":"Glycogen synthase kinase 3beta\/CCR6\u2010positive bone marrow cells correlate with disease activity in multicentric Castleman disease\u2010TAFRO","author":"Abe N","year":"2021","journal-title":"Br J Haematol"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010146821"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010eular.2246"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317725589"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010016\u20101979\u20101"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.53.57"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00149"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24242"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492743"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0b013e32834db525"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.49.4.m232"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010011\u20101388\u20108"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4703608"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41100\u2010018\u20100157\u20108"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.56.7991"},{"issue":"12","key":"e_1_2_11_50_1","first-page":"2490","article-title":"TAFRO syndrome showing cholangitis on liver biopsy","volume":"57","author":"Nagai Y","year":"2016","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2017.1930"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12856"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017009654"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010020\u20101204\u20109"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010019\u201002780\u20101"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201007\u2010862334"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8522\u201016"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010016\u20101978\u20102"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000931"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102019\u2010234155"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17868"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328\u2010021\u201001515\u20102"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201011\u2010748855"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201014\u20101678"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(14)70319\u20105"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271\u2010015\u20100120\u20105"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4655"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/24725625.2020.1789304"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28489"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.6455"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2962"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.284"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684\u2010017\u20100510\u20102"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010019\u201003120\u2010w"},{"issue":"3","key":"e_1_2_11_75_1","first-page":"519","article-title":"Fatal case of TAFRO syndrome associated with over\u2010immunosuppression: a case report and review of the literature","volume":"81","author":"Matsuhisa T","year":"2019","journal-title":"Nagoya J Med Sci"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.236.289"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.4710"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000011045"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2020.10.384"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci126091"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.7326\/l20\u20101051"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505458"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.15171\/ipp.2020.01"},{"issue":"10","key":"e_1_2_11_84_1","first-page":"2029","article-title":"Proposed diagnostic criteria, disease severity classification, and treatment strategy for a novel disorder; TAFRO syndrome","volume":"57","author":"Masaki Y","year":"2016","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730\u2010019\u201000400\u20109"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1206243"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8872774"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/24725625.2020.1717747"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.10.011"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.5414\/cncs109400"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.5850\u201020"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24015"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8360\u201016"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0116\u201017"},{"issue":"8","key":"e_1_2_11_95_1","first-page":"624","article-title":"A report of six TAFRO syndrome: clinical characteristics, diagnosis and treatment analysis","volume":"100","author":"Wu CB","year":"2020","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.39.64"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000006271"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.919536"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.05.004"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.12175"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.926721"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010020\u201002119\u20107"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4946"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13473"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqab191.323"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.14740\/jmc3784"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010016\u20102025\u2010z"},{"issue":"4","key":"e_1_2_11_108_1","first-page":"253","article-title":"TAFRO syndrome: a case report from Turkey and review of the literature","volume":"12","author":"Islamo\u011flu Z","year":"2018","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.173"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730\u2010017\u20100253\u20106"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehpc.2017.04.003"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010018\u20101814\u20109"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.03.021"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730\u2010018\u20100319\u20100"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1120389"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9484\u201017"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010019\u20101574\u20109"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010019\u201002604\u20102"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v8.i9.1656"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010020\u201002588\u20102"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.20065"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.5414\/cn110290"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.3075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T15:28:51Z","timestamp":1691594931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,3]]},"references-count":121,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/hon.3075"],"URL":"https:\/\/doi.org\/10.1002\/hon.3075","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3075\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3075\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3075\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3075\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,3]]},"assertion":[{"value":"2022-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}