{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:18Z","timestamp":1772118618083,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A prospective multicentre experience of early administration of anti\u2010SARS\u2010CoV\u20102 spike protein neutralizing monoclonal antibodies (MA) with efficacy among patients with hematological malignancies and early\u2010stage COVID\u2010 19 was reported by Weinbergerov\u00e1 et\u00a0al. The study validated the safety and efficacy of MA early use among hematological patients with newly diagnosed early\u2010stage COVID\u201019 in terms of alleviating infection course and decreasing mortality. However no reference to new variant (Delta and Omicron) or other MA (e.g., Sotrovimab) has been reported. We reported our monocentric experience of 8 aggressive lymphoma patients with Omicron infection, 7 of whom treated with this MA in our Institution between December 2021 and February 2022. Among the patients treated with Sotrovimab nobody experienced neither SARS\u2010CoV2 reactivation, nor other infectious events. One patients on active lymphoma treatment was hospitalized for pneumonia and treated with remdesivir. In 4\/8 patients negativization of molecular swab occurred concomitantly to symptoms resolution with a median of 5.25\u00a0days, while the other 4 patients remained persistently positive with a median of 26.3\u00a0days. In this group, in order to maintain the chemo\/chemoimmunotherapy (CT\/CIT) dose\u2010density, lymphoma treatment was reassumed independently on molecular swab analysis. SARS\u2010CoV\u20102 negativization occurred with a median of 7.7\u00a0days after the resumption of CT\/CIT. The one patient treated with remdesivir, although still positive to molecular swab, restarted R\u2010COMP regimen at symptoms resolution too, but experienced an Omicron pneumonia exacerbation. This is the first case series reported in literature of patients affected by Omicron variant in which Sotrovimab seems to provide a resolution of COVID\u201019 disease, even in patient with molecular swab positive persistence too. Patients with aggressive lymphoma histologies should not be deprived of the best available treatment of their disease after sotrovimab administration, even in the presence of a still positive Omicron swab.<\/jats:p>","DOI":"10.1002\/hon.3079","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T02:35:34Z","timestamp":1664159734000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reply to \u201csuccessful early use of anti\u2010SARS\u2010CoV\u20102 monoclonal neutralizing antibodies in SARS\u2010CoV\u20102 infected hematological patients\u2014A Czech multicenter experience\u201d: A case series of SARS\u2010CoV\u20102 Omicron infection and aggressive lymphoma in the Sotrovimab 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