{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:39:34Z","timestamp":1793659174263,"version":"4.5.1"},"reference-count":85,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970138"],"award-info":[{"award-number":["81970138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epigenetic alterations frequently participate in the onset of hematological malignancies. Histone deacetylases (HDACs) are essential for regulating gene transcription and various signaling pathways. Targeting HDACs has become a novel treatment option for hematological malignancies. Chidamide is the first oral selective HDAC inhibitor for HDAC1, HDAC2, HDAC3, and HDAC10 and was first approved for the treatment of R\/R peripheral T\u2010cell lymphoma by the China Food and Drug Administration in 2014. Chidamide was also approved under the name Hiyasta (HBI\u20108000) in Japan in 2021. In vitro studies revealed that chidamide could inhibit proliferation and induce apoptosis via cell cycle arrest and the regulation of apoptotic proteins. In clinical studies, chidamide was also efficacious in multiple myeloma, acute leukemia and myelodysplastic syndrome. This review includes reported experimental and clinical data on chidamide monotherapy or chidamide treatment in combination with chemotherapy for various hematological malignancies, offering a rationale for the renewed exploration of this drug.<\/jats:p>","DOI":"10.1002\/hon.3088","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T12:21:10Z","timestamp":1666009270000},"page":"301-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-6935","authenticated-orcid":false,"given":"Han\u2010Yu","family":"Cao","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematological Malignancies Translational Science Gehr Family Center for Leukemia Research Hematologic Malignancies and Stem Cell Transplantation Institute Beckman Research Institute City of Hope Medical Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Li","family":"Xue","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Ping","family":"Dai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191078"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.Mcr\u201018\u20100922"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa088"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv237"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20111685"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1691195"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2007.01.001"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018713"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.11.73"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111794"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620718816698"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210619"},{"key":"e_1_2_13_14_1","unstructured":"MarksPA RichonV RifkindRA.Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells.0027\u20108874(Print)."},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i8.1173"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010011\u20101766\u2010x"},{"key":"e_1_2_13_17_1","unstructured":"ChanTS TseE KwongYL.Chidamide in the treatment of peripheral T\u2010cell lymphoma.1178\u20106930(Print)."},{"key":"e_1_2_13_18_1","unstructured":"HeidemanMR LanciniC ProostN YanoverE JacobsH DannenbergJH.Sin3a\u2010associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.1592\u20108721(Electronic)."},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102559.2009.03290.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1247956"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201004187\u20105"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11947"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2200016"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010017\u20100552\u2010y"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2954"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.682436"},{"key":"e_1_2_13_27_1","unstructured":"CoiffierB ProB PrinceHM et\u00a0al.Results from a pivotal open\u2010label phase II study of romidepsin in relapsed or refractory peripheral T\u2010cell lymphoma after prior systemic therapy.1527\u20107755(Electronic)."},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106705"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095\u20103941.2020.0413"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000\u20109604.2021.05.08"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.835103"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.750323"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26499"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2979"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33761"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20102210\u20100"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00098"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010019\u20100493\u2010x"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.231"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S312249"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10301"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010022\u201001306\u20107"},{"issue":"3","key":"e_1_2_13_43_1","first-page":"574","article-title":"Chidamide, a novel histone deacetylase inhibitor, inhibits multiple myeloma cells proliferation through succinate dehydrogenase subunit A","volume":"9","author":"Sun Y","year":"2019","journal-title":"Am J Cancer Res"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3963"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684\u2010021\u20100877\u2010y"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.277152"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i5.1175"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.61602"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u20102414\u20103"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253\u20102727.2016.06.004"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201009\u2010692582"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10873"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2007.06667.x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23913"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13644"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010021\u201001079\u20105"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606095"},{"key":"e_1_2_13_58_1","unstructured":"KameiY XuL HeinzelT et\u00a0al.A CBP integrator complex mediates transcriptional activation and AP\u20101 inhibition by nuclear receptors.0092\u20108674(Print)."},{"key":"e_1_2_13_59_1","unstructured":"vom BaurE ZechelC HeeryD et\u00a0al.Differential ligand\u2010dependent interactions between the AF\u20102 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.0261\u20104189(Print)."},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1779"},{"key":"e_1_2_13_61_1","unstructured":"MartensJH BrinkmanA SimmerF et\u00a0al.PML\u2010RARalpha\/RXR alters the epigenetic landscape in acute promyelocytic leukemia.1878\u20103686(Electronic)."},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102003\u201007\u20102439"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4360"},{"key":"e_1_2_13_64_1","unstructured":"PetersonLF ZhangDE.The 8;21 translocation in leukemogenesis.0950\u20109232(Print)."},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111498108"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2014.39"},{"key":"e_1_2_13_67_1","unstructured":"YeJ ZhaJ ShiY et\u00a0al.Co\u2010inhibition of HDAC and MLL\u2010menin interaction targets MLL\u2010rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair.1868\u20107083(Electronic)."},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2019.12.07"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010019\u20100723\u20100"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010017\u20100377\u20108"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010020\u201001792\u20108"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201015\u20103057"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.243"},{"issue":"7","key":"e_1_2_13_74_1","first-page":"3169","article-title":"Chidamide, a novel histone deacetylase inhibitor, inhibits the viability of MDS and AML cells by suppressing JAK2\/STAT3 signaling","volume":"8","author":"Zhao S","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201002972\u20102"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2022.8277"},{"issue":"8","key":"e_1_2_13_77_1","first-page":"2567","article-title":"Effects of chidamide and its combination with decitabine on proliferation and apoptosis of leukemia cell lines","volume":"10","author":"Mao J","year":"2018","journal-title":"Am J Transl Res"},{"issue":"7","key":"e_1_2_13_78_1","first-page":"3461","article-title":"Chidamide plus decitabine synergistically induces apoptosis of acute myeloid leukemia cells by upregulating PERP","volume":"12","author":"Li Q","year":"2020","journal-title":"Am J Transl Res"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.18926\/amo\/63213"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.726926"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010020\u201000923\u20104"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.297"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2022.025"},{"key":"e_1_2_13_84_1","unstructured":"PommertLA.\u2010O SchaferES MalvarJ et\u00a0al.Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed\/refractory AML: report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium.1096\u20108652(Electronic)."},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12577"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.1827.1827"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.3088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T15:33:02Z","timestamp":1691595182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/hon.3088"],"URL":"https:\/\/doi.org\/10.1002\/hon.3088","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3088\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3088\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3088\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3088\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]},"assertion":[{"value":"2022-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}