{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:46:54Z","timestamp":1791395214351,"version":"4.3.3"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072587"],"award-info":[{"award-number":["82072587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2018085MH270"],"award-info":[{"award-number":["2018085MH270"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Endoplasmic reticulum (ER) stress has been reported to be transmitted from tumor cells to immune cells via exosome and implicated in immune escape. However, the influence of ER stress on monocytes in chronic lymphocytic leukemia (CLL) cells is largely unknown. Here, we observed the expression of ER stress markers (GRP78, ATF6, PERK, IRE1a, and XBP1s) in CLL cells. The increasing mRNA expression of these ER stress response components was positively correlated with more aggressive disease. Exosome from ER stress inducer tunicamycin (TM)\u2010primed CLL cells (ERS\u2010exo) up\u2010regulated the expression of ER stress marker on monocytes, indicating ER stress is transmissible in vitro via exosome. Treatment with ERS\u2010exo promoted the survival of monocytes and induced phenotypic changes with a significantly larger percentage of CD14\n                    <jats:sup>+<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocytes. Finally, we identified exosome\u2010mediated transfer of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) from ER stressed CLL cells into monocytes as a novel mechanism through which ERS\u2010exo regulated monocytes. Exosomal eNAMPT up\u2010regulated nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) production which subsequently activated SIRT1\u2010C\/EBP\u03b2 signaling pathway in monocytes. Our results suggest the role of ER stress in mediating immunological dysfunction in CLL.\n                  <\/jats:p>","DOI":"10.1002\/hon.3093","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T06:46:51Z","timestamp":1667371611000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exosomal NAMPT from chronic lymphocytic leukemia cells orchestrate monocyte survival and phenotype under endoplasmic reticulum stress"],"prefix":"10.1002","volume":"41","author":[{"given":"Jing","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Department of Oncology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Department of Hematology Xuanwu Hospital, Capital Medical University  Beijing 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