{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:15:26Z","timestamp":1790187326033,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Activated B cell (ABC) type diffuse large B cell lymphoma (DLBCL), double hit lymphoma (DHL) and double expressor lymphoma (DEL) have poor outcomes to frontline R\u2010CHOP but impact of these molecular features on outcomes of relapsed\/refractory (R\/R) disease is not well\u2010characterized. We evaluated the association of diagnostic cell of origin (COO), double hit and double expressor status with overall survival after first relapse in DLBCL patients who were enrolled into the Molecular Epidemiology Resource (MER) cohort. COO was available from immunohistochemistry (IHC) using Hans criteria or gene expression profiling (GEP) (Nanostring) on the diagnostic FFPE biopsy. Of 373 pts with R\/R DLBCL, 278 had COO by IHC: 152 were GCB, 107 were non\u2010GCB. One hundred and fourty had COO by GEP: 44 were ABC, 65 were GCB and 13 were unclassifiable. Nineteen out of 163 (12%) were DHL; 30 out of 135 (22%) had DEL. COO, either by IHC (2\u00a0years OS GCB: 45% [CI\n                    <jats:sub>95<\/jats:sub>\n                    : 38\u201354] vs. non\u2010GCB: 44% [CI\n                    <jats:sub>95<\/jats:sub>\n                    :36\u201355],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&gt;\u00a00.05) or GEP (2\u00a0years OS ABC: 42% [CI\n                    <jats:sub>95<\/jats:sub>\n                    : 29\u201359] vs. GCB: 40% [CI\n                    <jats:sub>95<\/jats:sub>\n                    : 30\u201354],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&gt;\u00a00.05), was not associated with difference in OS. DHL (2\u00a0years OS 16 [CI\n                    <jats:sub>95<\/jats:sub>\n                    :6\u201345] vs. 45% [CI\n                    <jats:sub>95<\/jats:sub>\n                    : 34\u201359],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) and DEL (2\u00a0years OS 33% [CI\n                    <jats:sub>95<\/jats:sub>\n                    : 20\u201356], vs. 50% [CI\n                    <jats:sub>95<\/jats:sub>\n                    : 41\u201360],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) had lower OS than non\u2010DHL and non\u2010DEL\/non\u2010DHL counterparts, respectively. COO by IHC or GEP was not associated with OS in R\/R DLBCL while DHL and DEL were adverse prognostic markers in DLBCL at first relapse.\n                  <\/jats:p>","DOI":"10.1002\/hon.3098","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T10:05:12Z","timestamp":1666951512000},"page":"39-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cell of origin is not associated with outcomes of relapsed or refractory diffuse large B cell lymphoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-2625","authenticated-orcid":false,"given":"Sanjal H.","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Hematology Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Hematology, Oncology and Transplantation University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Mwangi","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra N.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Bone Marrow Transplant University of Iowa Hospitals and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Department of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-2309","authenticated-orcid":false,"given":"Carrie A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-8341","authenticated-orcid":false,"given":"Yucai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Ansell","sequence":"additional","affiliation":[{"name":"Department of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4215-6500","authenticated-orcid":false,"given":"Thomas E.","family":"Witzig","sequence":"additional","affiliation":[{"name":"Department of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz S.","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Department of Hematology Mayo Clinic  Rochester Minnesota 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