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Vertebral augmentation procedures (VAP) can be subdivided into percutaneous vertebroplasty (VP) and balloon kyphoplasty (BKP). BKP involves the placement of orthopaedic balloons into the fractured vertebral body, creating a void into which polymethylmethacrylate bone cement is injected. This review outlines the management of spinal lesions in patients with MM, with a focus on the comparative risks and efficacy of vertebroplasty (VP) and balloon kyphoplasty (BKP). Soft tissue masses in MM are highly radiosensitive. Bisphosphonates and newer oncological therapies have decreased the indications for palliative radiotherapy, while spinal bracing can be utilised in selected cases to provide stability. BKP and VP provide equivalent long term pain control after MM vertebral compression fractures (VCF). BKP is superior to non\u2010operative management and VP for restoration of vertebral body height and prevention of segmental kyphosis. Current evidence suggests a greater degree of correction of kyphotic deformity and restoration of mid vertebral height (MVH) with BKP when compared with VP. The literature supports the use of BKP even in the presence of posterior vertebral body wall (PVBW) fractures, a group previously considered a contraindication to VAP. Superior functional outcomes have been reported in patients undergoing early versus delayed BKP (&lt;6\u20138\u00a0weeks). Current evidence supports a lower risk of cement extrusion with BKP than with VP, but serious complications following VAP are rare. MM spinal pathology should be managed in a multidisciplinary setting. Surgical decompression and instrumentation are rarely indicated, due to the radio\u2010sensitivity of soft tissue lesions in MM. BKP is a safe and effective procedure for VCF secondary to MM.<\/jats:p>","DOI":"10.1002\/hon.3102","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T12:29:19Z","timestamp":1669638559000},"page":"323-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of Vertebral Augmentation Procedures in the management of vertebral compression fractures secondary to multiple myeloma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-3488","authenticated-orcid":false,"given":"Kelechi C.","family":"Eseonu","sequence":"first","affiliation":[{"name":"Guy's and St. Thomas' Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaykar R.","family":"Panchmatia","sequence":"additional","affiliation":[{"name":"Guy's and St. Thomas' Hospitals  London 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