{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:28:19Z","timestamp":1785878899619,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ20H080003"],"award-info":[{"award-number":["LQ20H080003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970117"],"award-info":[{"award-number":["81970117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800121"],"award-info":[{"award-number":["81800121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The treatment of patients with refractory and\/or relapsed (R\/R) high\u2010risk myelodysplastic syndrome (HR\u2010MDS) remains a daunting clinical challenge. Venetoclax is a selective BCL\u20102 inhibitor, which combined with hypomethylating agents (HMAs), increased responses and prolonged survival in unfit and previously untreated acute myeloid leukemia. We performed a retrospective study of patients with R\/R HR\u2010MDS receiving combination azacytidine (AZA) plus 15\u2010days duration of venetoclax (VEN\u201015d) in order to determine their efficacy and toxicity in this context. We showed that the overall response rate was 57.2% (20\/35) and the median over survival was 14\u00a0months in R\/R MDS. The most common treatment\u2010emergent adverse events were peripheral blood cytopenias and infectious complications. Our retrospective study showed that the real\u2010world experience of treating R\/R MDS with AZA plus VEN\u201015d highlights an encouraging response rate with myelosuppression being the major toxicity. Of note, VEN\u201015d with AZA may salvage patients failing to respond optimally to HMAs and reduce the disease\u2010burden for subsequent allogeneic stem cell transplantation\u00a0in our analysis. These data of combination AZA plus VEN\u201015d in R\/R MDS warrant further prospective evaluation in clinical trials.<\/jats:p>","DOI":"10.1002\/hon.3112","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T13:59:35Z","timestamp":1671026375000},"page":"546-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["15\u2010days duration of venetoclax combined with azacitidine in the treatment of relapsed\/refractory high\u2010risk myelodysplastic syndromes: A retrospective single\u2010center study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8071-8175","authenticated-orcid":false,"given":"Chen","family":"Mei","sequence":"first","affiliation":[{"name":"Myelodysplastic Syndromes Diagnosis and Therapy Center the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Hematology the First Affiliated 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