{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:04Z","timestamp":1772118664147,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    COVID19 in patients affected by lymphoma represents an important challenge because of the higher mortality rate. Anti\u2010SARS\u2010CoV\u20102 monoclonal antibodies (anti\u2010S MoAbs) appear promising in this setting. We report a monocentric retrospective study including 176 patients affected by lymphoma which developed SARS\u2010CoV\u20102 infection since the start of COVID19 pandemic. Overall, mortality was 13.1%, with a decreasing trend between first waves to the last wave of pandemic (18.5% vs. 9.4%,\n                    <jats:italic>p<\/jats:italic>\n                    0.076). Patients receiving anti\u2010S MoAbs (41.3%) showed inferior mortality rate (overall survival, OS 93.2% vs. 82.7%,\n                    <jats:italic>p<\/jats:italic>\n                    0.025) with no serious toxicity, reduced documented pneumonia (26% vs. 33%,\n                    <jats:italic>p<\/jats:italic>\n                    0.005), and reduced need of oxygen support (14.5% vs. 35.7%,\n                    <jats:italic>p<\/jats:italic>\n                    0.003). Among patients who received 3 doses of vaccine, the employment of anti\u2010COVID MoAbs showed a trend of superior survival versus those who did not receive Anti\u2010S MoAbs (OS rates 97.3% vs. 84.2%,\n                    <jats:italic>p<\/jats:italic>\n                    0.064). On multivariate analysis, active\u00a0haematological disease (OS 72% (HR 2.49 CI 1.00\u20136.41), bendamustine exposure (OS 60% HR 4.2 CI 1.69\u201310.45) and at least one comorbidity (HR 6.53 CI 1.88\u201322.60) were independent prognostic factors for death. Our study confirms the adverse prognostic role of COVID\u201019 in lymphoma patients in presence of active disease, comorbidities and previous exposure to bendamustine. In our experience, anti\u2010S MoAbs represented a therapeutic option in vaccinated patients.\n                  <\/jats:p>","DOI":"10.1002\/hon.3113","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T19:49:21Z","timestamp":1671133761000},"page":"343-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of anti\u2010SARS\u2010CoV\u20102 monoclonal antibodies in the management of patients with lymphoma and COVID19: A retrospective study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-9635","authenticated-orcid":false,"given":"Giovanni Manfredi","family":"Assanto","sequence":"first","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Di Rocco","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Malfona","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Capriata","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Girardi","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna Maria","family":"D\u2019Elia","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Martelli","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Gentile","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Micozzi","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pulsoni","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Sapienza University of Rome  Rome 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