{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:38Z","timestamp":1772118578036,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012100","name":"Associazione Italiana Contro le Leucemie-Linfomi e Mieloma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Lugano classification for response assessment in lymphoma recommends the use of the 5\u2010point\u2010scale Deauville Score (DS) to assess response evaluation of end\u2010of\u2010treatment FDG\u2010PET\/CT (eotPET) in Hodgkin Lymphoma (HL); nevertheless, there is a paucity of data on its accuracy and reproducibility. We focus here on the cohort of advanced stage IIb\u2010IV HL patients enrolled in the HD0607 clinical trial (NCT identifier 00795613) that having had a negative interim PET performed 6 cycles of ABVD (Doxorubicin, Vinblastine, Vincristine and Dacarbazine) and then performed an eotPET. Negative patients were randomized to radiotherapy and no further treatment while positive patients were treated based on local policies. eotPET was re\u2010evaluated independently by two readers evaluated and progression free survival was analysed (PFS). eotPET of 254 patients were analysed. The median follow\u2010up was 43\u00a0months. The best receiver operator characteristics cut\u2010off values to distinguish positive and negative patients was 4. The area\u2010under\u2010the\u2010curve was 0.81 (95%CI, 0.70\u20130.91). Three\u2010years PFS was 0.95 (95% CI 0.90\u20130.97) in eotPET negative and 0.22 (95% CI 0.11\u20130.43) in eotPET positive. DS demonstrated a good reproducibility of positivity\/negativity between the readers consensus and local site evaluation where the agreement occurred on 95.0% of patients. The present study demonstrates that eotPET is an accurate tool to predict treatment outcome in HL and confirms the appropriateness of the Lugano classification for eotPET evaluation.<\/jats:p>","DOI":"10.1002\/hon.3117","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T16:09:26Z","timestamp":1671466166000},"page":"415-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictive value on advance hodgkin lymphoma treatment outcome of end\u2010of treatment FDG PET\/CT in the HD0607 clinical trial"],"prefix":"10.1002","volume":"41","author":[{"given":"Alberto","family":"Biggi","sequence":"first","affiliation":[{"name":"Nuclear Medicine Division Santa Croce e Carle Hospital  Cuneo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4394-5031","authenticated-orcid":false,"given":"Stephane","family":"Chauvie","sequence":"additional","affiliation":[{"name":"Medical Physics Division Santa Croce e Carle Hospital  Cuneo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Fallanca","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Division IRCSS Ospedale San Raffaele  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Guerra","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Division Ospedale San Gerardo  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Bergesio","sequence":"additional","affiliation":[{"name":"Medical Physics Division Santa Croce e Carle Hospital  Cuneo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Menga","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Division Ospedale Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Division Santa Croce e Carle Hospital  Cuneo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Gregianin","sequence":"additional","affiliation":[{"name":"Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Chiaravalloti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Division Tor Vergata University  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orazio","family":"Schillaci","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Division Tor Vergata University  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pavoni","sequence":"additional","affiliation":[{"name":"Haematology Division ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Patti","sequence":"additional","affiliation":[{"name":"Haematologiy. Division V. Cervello Hospital  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Picardi","sequence":"additional","affiliation":[{"name":"Clinical Medicine and Surgery Department Federico II University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Romano","sequence":"additional","affiliation":[{"name":"Hematology Division Policlinico Vittorio Emanuele Hospital  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Schiavotto","sequence":"additional","affiliation":[{"name":"Hematology Division S. 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