{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:05:13Z","timestamp":1784909113241,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004726","name":"Ministry of Health, British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ibrutinib\u2010associated atrial fibrillation (IRAF) emerged among the adverse events of major interests in ibrutinib\u2010treated patients as real\u2010world studies showed a higher incidence compared to clinical trials. We prospectively analyzed predictors of IRAF in 43 single\u2010center consecutive patients affected by chronic lymphocytic leukemia that started therapy with ibrutinib between 2015 and 2017. Key secondary endpoints were to describe the management of IRAF and survival outcomes. During a median follow\u2010up period of 52\u00a0months, we registered 45 CV events, with a total of 23 AF events in 13 patients (CI 30.0% (95% CI: 16.5\u201343.9)). Pre\u2010existent cardiovascular risk factors, in particular hypertension, a previous history of AF and a high Shanafelt risk score emerged as predictors of IRAF. Baseline echocardiographic evaluation of left atrial (LA) dimensions confirmed to predict IRAF occurrence and cut\u2010off values were identified in our cohort: 32\u00a0mm for LA diameter and 18\u00a0cm\n                    <jats:sup>2<\/jats:sup>\n                    for LA area. No difference in progression free survival and overall survival emerged in patients experiencing IRAF. Following AF, anticoagulation was started in all eligible patients, and cardioactive therapy was accordingly modified. Echocardiography represents a highly reproducible and widespread tool to be included in the work\u2010up of ibrutinib candidates; the identification of IRAF predictors represents a useful guide to clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/hon.3126","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T03:05:29Z","timestamp":1675998329000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predictors of ibrutinib\u2010associated atrial fibrillation: 5\u2010year follow\u2010up of a prospective study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-1015","authenticated-orcid":false,"given":"Veronica","family":"Mattiello","sequence":"first","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca\u2019 Granda Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Barone","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca\u2019 Granda Policlinico  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Giannarelli","sequence":"additional","affiliation":[{"name":"Facility of Epidemiology and Biostatistics Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Noto","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca\u2019 Granda Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cecchi","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca\u2019 Granda Policlinico  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9361-7397","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Rampi","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca\u2019 Granda Policlinico  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan 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