{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:04:54Z","timestamp":1789751094865,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The high cure rates of Hodgkin lymphoma (HL) make this oncological disease among those with the greatest number of long\u2010term survivors. This single\u2010institution study including 383 HL patients with up to 45\u00a0years of follow\u2010up, analyses the morbidity and mortality of this population after treatments in comparison with the overall Spanish population, and investigates whether it has changed over time stratifying by periods of time, as a consequence of therapeutic optimization. The median age was 34.8\u00a0years (range 15\u201387) with median overall survival of 30\u00a0years, significantly higher in women (HR 0.58, 95% CI 0.42\u20130.79) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0002). 185 late\u2010stage diseases were noted (35% patients), cardiovascular disease (CVD) being the most frequent (23.2%). 30% of patients developed at least one second malignant neoplasm (SMN) to give a total of 174 SMNs. 20.9% of the patients died from HL and 67.0% died from non\u2010HL causes (32.2% from SMN, 17% from CVD). The overall standardized mortality ratio (SMR) was 3.57 (95% CI: 3.0\u20134.2), with striking values of 7.73 (95% CI: 5.02\u20138.69) and of 14.75 (95% CI: 11.38\u201319.12) for women and patients &lt;30\u00a0years at diagnosis, respectively. Excluding HL as the cause of death, the SMRs of those diagnosed before 2000 and from 2000 were proved to be similar (3.88\n                    <jats:italic>vs<\/jats:italic>\n                    2.73), maintaining in this last period an unacceptable excess of mortality due to secondary toxicity in patients cured of HL. Our study confirm that HL treatment substantially reduces the life expectancy of patients cured of HL. In recent periods, despite therapeutic optimization, deaths from toxicity continue to occur, mainly from CVD and SMN. Risk\u2010factor monitoring should be intensified, prevention programs developed, and therapeutic optimization of LH investigated, especially in two vulnerable groups: those aged &lt;30\u00a0years at diagnosis, and women.\n                  <\/jats:p>","DOI":"10.1002\/hon.3131","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T03:58:07Z","timestamp":1679198287000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term outcomes in Hodgkin lymphoma survivors. Temporary trends and comparison with general population"],"prefix":"10.1002","volume":"41","author":[{"given":"Beatriz","family":"N\u00fa\u00f1ez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola Blanco","family":"Clemente","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Crist\u00f3bal","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Royuela","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Hospital Universitario Puerta de Hierro Majadahonda IDIPHISA. CIBERESP ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca Cantos S\u00e1nchez de","family":"Ibarg\u00fcen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge V.","family":"L\u00f3pez\u2010Ibor","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital de la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Traseira","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yago","family":"Garitaonaindia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Aguado","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-7660","authenticated-orcid":false,"given":"Mar\u00eda","family":"Torrente","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Parejo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Provencio","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Provencio","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Madrid 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