{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:13:02Z","timestamp":1785928382136,"version":"3.56.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014139","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","doi-asserted-by":"publisher","award":["PROYE18020BEA"],"award-info":[{"award-number":["PROYE18020BEA"]}],"id":[{"id":"10.13039\/501100014139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    While some follicular lymphoma (FL) patients do not require treatment or experience prolonged responses, others relapse early, and little is known about genetic alterations specific to patients with a particular clinical behavior. We selected 56 grade 1\u20133A FL patients according to their need of treatment or timing of relapse: never treated (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07), non\u2010relapsed (19), late relapse (14), early relapse or POD24 (11), and primary refractory (5). We analyzed 56 diagnostic and 12 paired relapse lymphoid tissue biopsies and performed copy number alteration (CNA) analysis and next generation sequencing (NGS). We identified six focal driver losses (1p36.32, 6p21.32, 6q14.1, 6q23.3, 9p21.3, 10q23.33) and 1p36.33 copy\u2010neutral loss of heterozygosity (CN\u2010LOH). By integrating CNA and NGS results, the most frequently altered genes\/regions were\n                    <jats:italic>KMT2D<\/jats:italic>\n                    (79%),\n                    <jats:italic>CREBBP<\/jats:italic>\n                    (67%),\n                    <jats:italic>TNFRSF14<\/jats:italic>\n                    (46%) and\n                    <jats:italic>BCL2<\/jats:italic>\n                    (40%). Although we found that mutations in\n                    <jats:italic>PIM1<\/jats:italic>\n                    ,\n                    <jats:italic>FOXO1<\/jats:italic>\n                    and\n                    <jats:italic>TMEM3<\/jats:italic>\n                    0A were associated with an adverse clinical behavior, definitive conclusions cannot be drawn, due to the small sample size. We identified common precursor cells harboring early oncogenic alterations of the\n                    <jats:italic>KMT2D<\/jats:italic>\n                    ,\n                    <jats:italic>CREBBP<\/jats:italic>\n                    ,\n                    <jats:italic>TNFRSF14<\/jats:italic>\n                    and\n                    <jats:italic>EP300<\/jats:italic>\n                    genes and 16p13.3\u2010p13.2 CN\u2010LOH. Finally, we established the functional consequences of mutations by means of protein modeling (\n                    <jats:italic>CD7<\/jats:italic>\n                    <jats:italic>9B<\/jats:italic>\n                    ,\n                    <jats:italic>PLCG2<\/jats:italic>\n                    ,\n                    <jats:italic>PIM1<\/jats:italic>\n                    ,\n                    <jats:italic>MCL1<\/jats:italic>\n                    and\n                    <jats:italic>IRF8<\/jats:italic>\n                    ). These data expand the knowledge on the genomics behind the heterogeneous FL population and, upon replication in larger cohorts, could contribute to risk stratification and the development of targeted therapies.\n                  <\/jats:p>","DOI":"10.1002\/hon.3132","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T07:26:48Z","timestamp":1680161208000},"page":"631-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Genomic landscape of follicular lymphoma across a wide spectrum of clinical behaviors"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-4971","authenticated-orcid":false,"given":"Pablo","family":"Mozas","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona\u2010Institut d\u2019Investigacions 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