{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:18:48Z","timestamp":1783577928102,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fluorescence in situ hybridization (FISH) to detect the recurrent cytogenetics abnormalities deletion 13q, trisomy 12, deletion 11q, and deletion 17p is important for prognostication in chronic lymphocytic leukemia (CLL). A subset of patients are negative for each of these abnormalities (normal 12\/13\/11\/17 FISH), and outcomes are heterogenous within this group. To elucidate variables important for prognostication in this subgroup we conducted a retrospective analysis of 280 treatment\u2010na\u00efve CLL patients with normal standard CLL FISH results. In a multivariable model, advanced Rai stage (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.04, hazard ratio [HR] 1.24 (95% confidence interval [CI]\u00a01.01\u20131.53)), unmutated immunoglobulin heavy chain gene (\n                    <jats:italic>IGHV<\/jats:italic>\n                    ) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001, HR 5.59 (95% CI 3.63\u20138.62)) and\n                    <jats:italic>IGH<\/jats:italic>\n                    rearrangement by FISH (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.02, HR 2.56 (95% CI 1.20\u20135.48)) were significantly associated with shorter time to first treatment. In a multivariable model for overall survival, increasing age at 5\u2010year increments (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001, HR 1.55 (95% CI 1.25\u20131.93)), unmutated\n                    <jats:italic>IGHV<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.01, HR 5.28 (95% CI 1.52\u201318.35)) and gain of\n                    <jats:italic>REL<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.01, HR 4.08 (5% CI 1.45\u201311.49)) were significantly associated with shorter survival. Our study identifies variables important for refining prognosis for CLL patients with normal standard CLL FISH results.\n                  <\/jats:p>","DOI":"10.1002\/hon.3134","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T08:35:33Z","timestamp":1680510933000},"page":"771-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Refining prognosis in chronic lymphocytic leukemia with normal Fluorescence in situ hybridization results"],"prefix":"10.1002","volume":"41","author":[{"given":"Matthew R.","family":"Avenarius","sequence":"first","affiliation":[{"name":"Department of Pathology College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-0655","authenticated-orcid":false,"given":"Jonathan","family":"Hyak","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Byrd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema A.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grever","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Kittai","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry A.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-3780","authenticated-orcid":false,"given":"Dan","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-2780","authenticated-orcid":false,"given":"Weiqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyla A.","family":"Heerema","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne V.","family":"Abruzzo","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Woyach","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-6069","authenticated-orcid":false,"given":"Cecelia R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200012283432602"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13933"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201011\u2010395269"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404935"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201009\u2010873083"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.03.042"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131448"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.217307"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201003\u2010489518"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010536"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404457"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.07.006"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000707"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2010.08420.x"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2008.07227.x"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133270"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2011.08789.x"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001237\u2010x"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.788761"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2022.100930"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001561\u2010w"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:46:22Z","timestamp":1696927582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/hon.3134"],"URL":"https:\/\/doi.org\/10.1002\/hon.3134","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3134\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3134\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3134\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3134\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"2023-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}