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Several novel agents, polatuzumab vedotin, tafasitamab, loncastuximab tesirine, and selinexor, have been approved and offer new opportunities for this difficult to treat population. Studies are evaluating combination of these agents with chemotherapy and other emerging therapies. Additionally, advances in our understanding of DLBCL biology, genetics, and immune microenvironment have allowed for the identification of new therapeutic targets like <jats:italic>Ikaros<\/jats:italic> and <jats:italic>Aiolos<\/jats:italic>, IRAK4, MALT1, and CD47 with several agents in ongoing clinical trials. In this chapter we review updated data supporting the use of the approved agents and discuss other emerging novel therapies for patients with R\/R DLBCL.<\/jats:p>","DOI":"10.1002\/hon.3143","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T21:16:34Z","timestamp":1686345394000},"page":"92-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Novel agents in relapsed\/refractory diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"41","author":[{"given":"Gaurav","family":"Varma","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology Department of Medicine New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Oncology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana H.","family":"Advani","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Oncology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"NCCN. 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