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These interactions are mediated through the B\u2010cell antigen receptor (BCR), C\u2010X\u2010C chemokine receptor type 4 (CXCR4), and a variety of integrins, including VLA\u20104. Exciting each receptor type leads to activation of Bruton's tyrosine kinase (BTK), which in turn helps initiate trophic signals that prevent cell death and promote cell activation and growth as well as allowing cells to return to anatomic sites for rescue signals. These represent the two major functional actions targeted by inhibitors of Btk. Here we relate some of the therapeutic actions of ibrutinib, a Btk inhibitor that is extremely helpful for patients with CLL, certain Diffuse Large B\u2010cell Lymphomas (ABC type), and other non\u2010Hodgkin's lymphomas, emphasizing that ibrutinib's value results from blocking beneficial signals, not by inducing lethal ones.<\/jats:p>","DOI":"10.1002\/hon.3144","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T21:16:34Z","timestamp":1686345394000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Functional consequences of inhibition of Bruton's tyrosine kinase by ibrutinib in chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"41","author":[{"given":"Shih\u2010Shih","family":"Chen","sequence":"first","affiliation":[{"name":"Karches Center for Oncology Research The Feinstein Institutes for Medical Research  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chiorazzi","sequence":"additional","affiliation":[{"name":"Karches Center for Oncology Research The Feinstein Institutes for Medical Research  Manhasset New York USA"},{"name":"Departments of Molecular Medicine and of Medicine Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York 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