{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:50:04Z","timestamp":1787500204356,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017592","name":"Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2018ZDXM\u2010SF\u2010039"],"award-info":[{"award-number":["2018ZDXM\u2010SF\u2010039"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chimeric antigen receptor (CAR)\u2010reprogrammed T cell therapy is a novel and powerful treatment against hematological malignancies. Cytokine release syndrome (CRS) and other potentially life\u2010threatening toxicities are known side effects which need appropriate management and supportive care. Coagulopathy is a common and severe CAR\u2010T\u2010related adverse event, while a comprehensive profile of coagulopathy in patients with multiple myeloma (MM) undergoing CAR\u2010T cell therapy has not been reported. Therefore, we performed a comprehensive analysis of coagulopathy in 51 patients with r\/r MM given anti\u2010B cell maturation antigen\u00a0CAR\u2010T cell therapy. We found that 49% of patients had coagulation disorders, and 29% of patients experienced disseminated intravascular coagulation (DIC). Severe CRS, abnormal liver function and higher tumor burden were risk factors for the CAR\u2010T\u2010related coagulopathy. We found that the serum IL\u20106 level and alanine aminotransferase level were potential indicators for CAR\u2010T\u2010related DIC. Furthermore, we found that coagulation disorders occurred within 1\u00a0month after CAR\u2010T cell infusion, mainly between days 10 and 13, which was 2\u22125\u00a0days later than the beginning of CRS and simultaneous with the beginning of abnormal liver function and the peak of CRS. In addition, although patients with coagulation dysfunction had a trend for better outcomes and prognosis, no statistical significance was found. In conclusion, our research provided a comprehensive understanding of CAR\u2010T\u2010related coagulopathy in MM. Upon timely and standardized treatment, coagulopathy was manageable in most cases.<\/jats:p>","DOI":"10.1002\/hon.3155","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T01:14:29Z","timestamp":1682471669000},"page":"704-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A comprehensive analysis of coagulopathy during anti\u2010B cell maturation antigen chimeric antigen receptor\u2010T therapy in multiple myeloma, a retrospective study based on LEGEND\u20102"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-829X","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 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Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-9187","authenticated-orcid":false,"given":"Wanggang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-3806","authenticated-orcid":false,"given":"Aili","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"National\u2010Local Joint Engineering Research Center of Bio Diagnostics and Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Department of Tumor and Immunology in Precision Medical Institute Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-4204","authenticated-orcid":false,"given":"Fangxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 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