{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:45:07Z","timestamp":1774014307272,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the present manuscript Gallamini et al. comment the results of three large, phase III, randomized clinical trials in early\u2010stage favorable Hodgkin Lymphoma (HL), aimed at exploring the non\u2010inferiority of ABVD chemotherapy alone compared to combined\u2010modality treatment with ABVD and Involved Field\/Node Radiotherapy (INRT). The authors also report the preliminary results of risk\u2010stratification in the first 60 enrolled patients in the phase 2, prospective, international study RAFTING: RAdiotherapy Free Treatment IN Good\u2010prognosis early\u2010stage HL (National Trial Identifier 04866654). In this trial patients are stratified, before treatment onset, according to the risk of therapy failure in a single patient basis, taking into account non only the results of interim and End\u2010of\u2010Therapy PET, but also the value of new metrics extracted from the baseline PET\/CT such as the Large Nodal Mass (LNM) and Total Metabolic Tumor Volume (TMTV). Treatment intensity, consisting in ABVD chemotherapy, INRT and Nivolumab maintenance, is modulated on the presence\/absence of the above factors, in a personalized\u2010medicine approach. The most frequently detected factors driving treatment intensity were LNM and TMTV, while the results of interim and end\u2010of\u2010treatment PET were also determinant, albeit in a lower percentage of cases.<\/jats:p>","DOI":"10.1002\/hon.3158","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T07:34:34Z","timestamp":1681976074000},"page":"608-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Revisiting the predictive role of 18F\u2010fluorodeoxyglucose positron emission tomography\/computerized tomography on treatment outcome in early\u2010stage favorable Hodgkin lymphoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-7412","authenticated-orcid":false,"given":"Andrea","family":"Gallamini","sequence":"first","affiliation":[{"name":"Onco\u2010Hematology Department A. Lacassagne Cancer Center  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-5404","authenticated-orcid":false,"given":"Axel","family":"Sudria","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology Department A. Lacassagne Cancer Center  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Kurlapski","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation \u2013 Gdansk University  Gdansk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauris","family":"Gastaud","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology Department A. Lacassagne Cancer Center  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation\u20102016.1.323"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.24272"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1505949"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.09.048"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1408648"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.68.6394"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.51.9298"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.00964"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201006\u20102252"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201010\u2010314260"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hs9.0000890652.56016.97"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq549"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20150983"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:46:12Z","timestamp":1696927572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,20]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/hon.3158"],"URL":"https:\/\/doi.org\/10.1002\/hon.3158","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3158\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3158\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3158\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3158\/v1\/review1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,20]]},"assertion":[{"value":"2023-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}