{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:22Z","timestamp":1772118622014,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) which is characterized by specific clinical and biological features. Typical APL cases are caused by\n                    <jats:italic>PML<\/jats:italic>\n                    ::\n                    <jats:italic>RARA<\/jats:italic>\n                    fusion gene and are exquisitely sensitive to all\u2010trans retinoic acid (ATRA) and arsenic trioxide (ATO). Rarely, APLs are caused by atypical fusions involving\n                    <jats:italic>RARA<\/jats:italic>\n                    or, in fewer cases still, fusions involving other members of the retinoic acid receptors (\n                    <jats:italic>RARB<\/jats:italic>\n                    or\n                    <jats:italic>RARG<\/jats:italic>\n                    ). To date, seven partner genes of\n                    <jats:italic>RARG<\/jats:italic>\n                    have been reported in a total of 18 cases of variant APL. Patients with\n                    <jats:italic>RARG<\/jats:italic>\n                    fusions showed distinct clinical resistance to ATRA and had poor outcomes. Here, we report\n                    <jats:italic>PRPF19<\/jats:italic>\n                    gene as a novel partner of\n                    <jats:italic>RARG<\/jats:italic>\n                    and identify a rare interposition\u2010type gene fusion in a variant APL patient with a rapidly fatal clinical course. The incomplete ligand\u2010binding domain of RARG in the fusion protein may account for the clinical ATRA resistance in this patient. These results broaden the spectrum of variant APL associated molecular aberrations. Accurately and timely identification of these rare gene fusions in variant APL is essential to guide therapeutic decisions.\n                  <\/jats:p>","DOI":"10.1002\/hon.3170","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T02:52:31Z","timestamp":1683082351000},"page":"784-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Report of\n                    <i>PRPF19<\/i>\n                    as a novel partner of\n                    <i>RARG<\/i>\n                    and the recurrence of interposition\u2010type fusion in variant acute promyelocytic leukemia"],"prefix":"10.1002","volume":"41","author":[{"given":"Huanling","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Emergency Center Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Lu Daopei Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongchen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panxiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Yuan","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiancheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-3405","authenticated-orcid":false,"given":"Xue","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Lu Daopei Institute of Hematology  Beijing China"},{"name":"Division of Pathology &amp; Laboratory Medicine Hebei Yanda Lu Daopei Hospital  Langfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.871590"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2066825"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281766"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080924"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040967"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.321"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.871590"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.05.001"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010019\u20100456\u2010z"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25689"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1011023"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:46:27Z","timestamp":1696927587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/hon.3170"],"URL":"https:\/\/doi.org\/10.1002\/hon.3170","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3170\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3170\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3170\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3170\/v1\/review1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"2023-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}