{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:36:04Z","timestamp":1780360564211,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010824","name":"Associazione Angela Serra per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We conducted a post hoc analysis of the FOLL12 trial to determine the impact of different initial immunochemotherapy (ICT) regimens on patient outcomes. Patients were selected from the FOLL12 trial, which included adults with stage II\u2013IV follicular lymphoma (FL) grade 1\u20133a and high tumor burden. Patients were randomized 1:1 to receive either standard ICT followed by rituximab maintenance (RM) or the same ICT followed by a response\u2010adapted approach. ICT consisted of rituximab\u2010bendamustine (RB) or rituximab, cyclophosphamide, doxorubicin, and prednisone (R\u2010CHOP), per physician's decision. A total of 786 patients were included in this analysis, 341 of whom received RB and 445 R\u2010CHOP. RB was more frequently prescribed to older subjects, females, patients without bulky disease, and those with grade 1\u20132 FL. After a median of 56\u00a0months of follow\u2010up, R\u2010CHOP and RB had similar progression\u2010free survival (PFS) (Hazard Ratio for RB 1.11, 95% CI 0.87\u20131.42,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.392). Standard RM was associated with improved PFS compared to response\u2010adapted management both after R\u2010CHOP and RB. Grade 3\u20134 hematologic adverse events were more frequent with R\u2010CHOP during induction treatment and more frequent with RB during RM. Grade 3\u20134 infections were more frequent with RB. RB was also associated with a higher incidence of transformed FL. R\u2010CHOP and RB showed similar activity and efficacy, but with different safety profiles and long\u2010term events, suggesting that the treating physician should carefully select the most appropriate chemotherapy regimen for each patient based on patient's individual characteristics, choices, and risk profile.\n                  <\/jats:p>","DOI":"10.1002\/hon.3184","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T23:54:46Z","timestamp":1685318086000},"page":"655-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of immunochemotherapy with R\u2010bendamustine or R\u2010CHOP for treatment na\u00efve advanced\u2010stage follicular lymphoma: A subset analysis of the FOLL12 trial by Fondazione Italiana Linfomi"],"prefix":"10.1002","volume":"41","author":[{"given":"Maria E.","family":"Nizzoli","sequence":"first","affiliation":[{"name":"Hematology Unit Azienda Unit\u0430 Sanitaria Locale\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-9922","authenticated-orcid":false,"given":"Martina","family":"Manni","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ghiggi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-8004","authenticated-orcid":false,"given":"Alessandro","family":"Pulsoni","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University \u2010 UOC Ematologia S.M. Goretti Hospital  Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Musuraca","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-5927","authenticated-orcid":false,"given":"Michele","family":"Merli","sequence":"additional","affiliation":[{"name":"Hematology University Hospital Ospedale di Circolo e Fondazione Macchi\u2010ASST Sette Laghi University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catello","family":"Califano","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia P.O. Pagani  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Bari","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno\u2010Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Massaia","sequence":"additional","affiliation":[{"name":"SC Ematologia AO S. Croce e Carle  Cuneo Italy"},{"name":"Centro di Biotecnologie Molecolari University of Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-4339","authenticated-orcid":false,"given":"Annarita","family":"Conconi","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale degli Infermi  Biella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellegrino","family":"Musto","sequence":"additional","affiliation":[{"name":"Hematology, IRCCS CROB of Rionero in Vulture  Rionero in Vulture Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Mannina","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Papardo\u2014UOC di Ematologia  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommasina","family":"Perrone","sequence":"additional","affiliation":[{"name":"Unit of Hematology and Stem Cell Transplantation AOUC Policlinico  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Re","sequence":"additional","affiliation":[{"name":"Division od Immuno\u2010Haematology AOU Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Gini","sequence":"additional","affiliation":[{"name":"Clinic of Hematology AOU delle Marche\u2010 Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Capponi","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Vitolo","sequence":"additional","affiliation":[{"name":"Medical Oncology Candiolo Cancer Institute FPO\u2010IRCCS  Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara V.","family":"Usai","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Oncologico Armando Businco  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero M.","family":"Stefani","sequence":"additional","affiliation":[{"name":"Hematology Unit General Hospital Ca\u2019 Foncello  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Clinica Ematologica Ospedale Policlinico San Martino  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Liberati","sequence":"additional","affiliation":[{"name":"Oncohematology Unit University of Perugia Azienda Ospedaliera S.Maria Terni  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Pennese","sequence":"additional","affiliation":[{"name":"Lymphoma Unit Department of Hematology Ospedale Spirito Santo  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pastore","sequence":"additional","affiliation":[{"name":"UOC Ematologia con Trapianto Brindisi  Brindisi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Skrypets","sequence":"additional","affiliation":[{"name":"Hematology Unit IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Catellani","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Fondazione Italiana Linfomi Onlus  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Unit\u0430 Sanitaria Locale\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.11.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201011\u2010531327"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00605"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)61763\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(10)62175\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01073"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01234"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.3991"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.8960"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2298"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm511"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(18)30090\u20105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.7163"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000258"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15720"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614598"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:46:43Z","timestamp":1696927603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,28]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/hon.3184"],"URL":"https:\/\/doi.org\/10.1002\/hon.3184","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3184\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3184\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3184\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3184\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,28]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}