{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:26:25Z","timestamp":1783056385933,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cytokine release syndrome (CRS), immune effector cell\u2010associated neurotoxicity syndrome (ICANS) and neutropenia are common toxicities associated with chimeric antigen receptor T (CAR\u2010T) cell therapy. The role of granulocyte colony stimulating factor (G\u2010CSF) in CAR\u2010T\u2010cell\u2010treated patients remains unclear. To explore the efficacy and safety of early G\u2010CSF administration in patients with relapsed\/refractory B\u2010cell acute lymphoblastic leukemia (R\/R B\u2010ALL) who were receiving autologous anti\u2010CD19 CAR\u2010T cells, we retrospectively collected and summarized clinical data to compare patients receiving G\u2010CSF within 14\u00a0days (early G\u2010CSF group) to patients receiving later or no G\u2010CSF (control group) after their CART infusion. The results showed that there was no significant difference in the incidence and duration of neutropenia between the early G\u2010CSF group and the control group (77% vs. 63%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.65; 8 vs. 4\u00a0days,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.37, respectively). However, the incidence and duration of CRS were significantly higher in the early G\u2010CSF group than in the control group (81% vs. 38%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.03; 3 vs. 0\u00a0days,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004, respectively). Moreover, early G\u2010CSF application had no significant effect on the expansion and efficacy of CAR\u2010T cells. In conclusion, our study suggested that early G\u2010CSF administration did not reduce the incidence and duration of neutropenia but rather increased the incidence and duration of CRS.\n                  <\/jats:p>","DOI":"10.1002\/hon.3188","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T01:10:31Z","timestamp":1685581831000},"page":"933-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early granulocyte colony stimulating factor administration increases the risk of cytokine release syndrome in acute lymphoblastic leukemia patients receiving anti\u2010CD19 chimeric antigen receptor T\u2010cell therapy"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9855-0291","authenticated-orcid":false,"given":"Manxiong","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Hematology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Shantou University Medical College Shantou University  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanfang","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1709866"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000000568"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.927153"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010019\u20100487\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010015\u20102686\u20109"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100041\u20107"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26313"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010020\u201001006\u2010x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001526\u20100"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.01992"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229781"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201005\u2010552729"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.148"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201006\u2010793141"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33356"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010022\u201000741\u20102"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.cd\u201017\u20101319"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.361"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1407222"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1709919"}],"container-title":["Hematological 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