{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:45Z","timestamp":1772118525647,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical or biological parameters useful to predict progression during treatment in real\u2010life setting with ibrutinib, idelalisib and venetoclax in relapsed\/refractory chronic lymphocytic leukemia (CLL) are still debated. We conducted a multi\u2010center retrospective study on CLL patients treated with ibrutinib and\/or idelalisib who were switched to venetoclax for progression or due to adverse events to identify any clinical and\/or biological parameters useful to predict progression during treatment with venetoclax. Of all the 128 evaluable patients, 81 had received ibrutinib prior to switching to venetoclax, 35 had received idelalisib and 12 both. When comparing the three subgroups, we did not notice any statistical difference in terms of clinical or biological features. No variable at baseline and at different time points during the follow\u2010up (at 6, 12, 18 and 24\u00a0months) was found to predict progression nor to have significance for Progression Free Survival (PFS) in the ibrutinib group and in the idelalisib group and in subgroups according to the line of treatment. Analyzing the data of the venetoclax treatment, after a median follow up of 14.3\u00a0months, median PFS was not reached and estimated 3\u2010year PFS was 54%. Of the 128 patients treated with venetoclax, 28 (22%) experienced progressive disease. At multivariate analysis for predictive factors for progression, lymph node diameter &gt;56.5 mm before starting treatment emerged as an independent risk factor for progression. The lymph node predictive role for progression during venetoclax treatment could be a new parameter that deserves to be investigate in future studies.<\/jats:p>","DOI":"10.1002\/hon.3199","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T06:18:45Z","timestamp":1688192325000},"page":"877-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lymphadenopathy as a predictor of progression during venetoclax treatment in chronic lymphocytic leukemia. A\u00a0campus chronic lymphocytic leukemia study"],"prefix":"10.1002","volume":"41","author":[{"given":"Francesco","family":"Autore","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idanna","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Reda","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Visentin","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candida","family":"Vitale","sequence":"additional","affiliation":[{"name":"A.O.U. Citt\u00e0 della Salute e della Scienza di Torino  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Piciocchi","sequence":"additional","affiliation":[{"name":"Fondazione GIMEMA  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-9009","authenticated-orcid":false,"given":"Alberto","family":"Fresa","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica M. A.","family":"Leone","sequence":"additional","affiliation":[{"name":"A.O. 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Consorziale Policlinico di Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Arcispedale Santa Maria Nuova IRCCS  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Angeletti","sequence":"additional","affiliation":[{"name":"Ospedale S. Maria di Terni  Terni Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria","family":"De Paolis","sequence":"additional","affiliation":[{"name":"A.O. Vito Fazzi  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Malerba","sequence":"additional","affiliation":[{"name":"A.O. Ospedali San Salvatore di Pesaro  Pesaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Chiurazzi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Federico II  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Loseto","sequence":"additional","affiliation":[{"name":"IRCCS Oncologico di Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioacchino","family":"Catania","sequence":"additional","affiliation":[{"name":"A.O.N. SS Antonio e Biagio e C. 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