{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:09Z","timestamp":1791895569926,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The reliability and safety of front\u2010line ultrasonography guided core needle biopsy (UG\u2010CNB) performed with specific uniform approach have never been evaluated in a large series of patients with lymphadenopathies suspected of lymphoma. The aim of this study was to assess the overall accuracy of UG\u2010CNB in the lymph node histological diagnosis, using a standard reference based on pathologist consensus, molecular biology, and\/or surgery. We retrospectively checked the findings concerning the application of lymph node UG\u2010CNB from four Italian clinical units that routinely utilized 16\u2010gauge diameter modified Menghini needle under power\u2010Doppler ultrasonographic guidance. A data schedule was sent to all centers to investigate the information regarding techniques, results, and complications of lymph node UG\u2010CNB in untreated patients over a 12\u2010year period. Overall, 1000 (superficial target,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0750; deep\u2010seated target,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0250) biopsies have been evaluated in 1000 patients; other 48 biopsies (4.5%), screened in the same period, were excluded because inadequate for a confident histological diagnosis. Most patients were suffering from lymphomas (aggressive B\u2010cell non\u2010Hodgkin lymphoma [aBc\u2010NHL], 309 cases; indolent B\u2010cell [iBc]\u2010NHL, 279 cases; Hodgkin lymphoma [HL], 212 cases; and nodal peripheral T\u2010cell [NPTC]\u2010NHL, 30 cases) and 100 cases from metastatic carcinoma; 70 patients had non\u2010malignant disorders. The majority of CNB results met at least one criterion of the composite reference standard. The overall accuracy of the micro\u2010histological sampling was 97% (95% confidence interval: 95%\u201398%) for the series. The sensitivity of UG\u2010CNB for the detection of aBc\u2010NHL was 100%, for iBc\u2010NHL 95%, for HL 93%, and for NPTC\u2010NHL 90%, with an overall false negative rate of 3.3%. The complication rate was low (6% for all complications); no patient suffered from biopsy\u2010related complications of grade &gt;2 according to the Common Terminology Criteria for Adverse Events. Lymph node UG\u2010CNB as mini\u2010invasive diagnostic procedure is effective with minimal risk for the patient.\n                  <\/jats:p>","DOI":"10.1002\/hon.3204","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T02:25:18Z","timestamp":1688696718000},"page":"817-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ultrasonography\u2010guided core\u2010needle biopsy of lymphadenopathies suspected of lymphoma: Analysis on diagnostic efficacy and safety of 1000 front\u2010line biopsies in a multicenter Italian study"],"prefix":"10.1002","volume":"41","author":[{"given":"Marco","family":"Picardi","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-4263","authenticated-orcid":false,"given":"Claudia","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vigliar","sequence":"additional","affiliation":[{"name":"Department of Public Health Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pio","family":"Zeppa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Salerno University Medical School  Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imma","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Department of Mental and Physical Health and Preventive Medicine University of Campania \u201cL. Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novella","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Della Pepa","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Pio","family":"Abagnale","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Ciriello","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Muccioli\u2010Casadei","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Public Health Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences Federico II University Medical School  Naples 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