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We assessed patient preferences for treatment attributes and evaluated associations with disease stage, treatment line, and socio\u2010demographic characteristics in a cross sectional, observational study conducted at 16 Italian hematology centers. Study visits occurred between February and July 2020; 401 adult patients with CLL (201 Watch and Wait (W&amp;W), 200 treated) participated in a discrete choice experiment (DCE), composed of 8 choices between pairs of treatment profiles with different levels of 5 attributes of currently available CLL treatments (length of response, route and duration of administration, risk of side effects including diarrhea, infections, or organ damage). Health\u2010related quality of life was assessed with the EQ\u20105D\u20105L, EORTC QLQ\u2010C30 and QLQ CLL\u201016. Previously treated patients had longer disease duration (7 vs. 5\u00a0years), higher prevalence of serious comorbidities (45.5% vs. 36.2%) and high\u2010risk molecular markers (unmutated IGHV 55.6% vs. 17.1%; TP53 mutation 15.2% vs. 4.0%). Health\u2010related quality of life scores were similar between groups. In the DCE, W&amp;W patients rated \u201cpossible occurrence of infections\u201d highest (relative importance [RI]\u00a0=\u00a036.2%), followed by \u201ctreatment and relevant duration\u201d (RI\u00a0=\u00a028.0%) and \u201cprogression\u2010free survival (PFS)\u201d (RI\u00a0=\u00a016.9%). Previously treated patients rated \u201ctreatment and relevant duration\u201d highest (RI\u00a0=\u00a033.3%), followed by \u201cpossible occurrence of infections\u201d (RI\u00a0=\u00a028.8%), \u201cpossible occurrence of organ damage\u201d (RI\u00a0=\u00a019.4%), and \u201cPFS\u201d (RI\u00a0=\u00a09.8%). Concern over infection was rated highest overall; unexpectedly PFS was not among the most important criteria in either group, suggesting that the first COVID\u201019 pandemic wave may have influenced patient preferences and concerns about CLL therapy options.<\/jats:p>","DOI":"10.1002\/hon.3216","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:47:58Z","timestamp":1695970078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Patients' preferences for chronic lymphocytic leukemia treatment: The CHOICE study"],"prefix":"10.1002","volume":"42","author":[{"given":"Paolo","family":"Sportoletti","sequence":"first","affiliation":[{"name":"Institute of Hematology and Center for Hemato\u2010Oncology Research University of Perugia and Santa Maria della Misericordia Hospital  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-1396","authenticated-orcid":false,"given":"Luca","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Hematology Institute Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Chiarenza","sequence":"additional","affiliation":[{"name":"Division of Hematology Ferrarotto Hospital  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Universit\u00e0 del Piemonte Orientale and Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Albi","sequence":"additional","affiliation":[{"name":"Strategic Research Programme in CLL Division of Experimental Oncology IRCCS Ospedale San Raffaele and Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Romana","family":"Mauro","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine 'Sapienza' University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-2573","authenticated-orcid":false,"given":"Livio","family":"Trentin","sequence":"additional","affiliation":[{"name":"Hematology Section Department of Medicine Azienda Ospedale Universit\u00e0 Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Vallisa","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Oncology and Hematology Guglielmo da Saliceto Hospital  Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Pane","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-1308","authenticated-orcid":false,"given":"Antonio","family":"Cuneo","sequence":"additional","affiliation":[{"name":"Hematology Section Department of Medical Sciences Azienda Ospedaliera\u2010Universitaria Arcispedale S. 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