{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:08:42Z","timestamp":1792372122796,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18ek0510023h0002"],"award-info":[{"award-number":["18ek0510023h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Allogeneic hematopoietic stem cell transplantation (HCT) remains the only potential curative therapeutic modality for advanced myelodysplastic syndrome (MDS). Within HCT, the advancement of cord blood transplantation (CBT) procedures has resulted in a drastic expansion of CBT as a donor source for MDS. However, data comparing matched sibling donors (MSDs) HCT with CBT for advanced MDS, which was defined as refractory anemia with an excess of blasts (RAEB)\u20101 and RAEB\u20102 according to the World Health Organization classification at the time of HCT, have not been explored. We retrospectively compared survival and other posttransplant outcomes in 999 adult patients with advanced MDS after receiving allogeneic HCT in Japan between 2011 and 2020, using either MSD (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0331) or single\u2010unit unrelated cord blood (UCB) (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0668). In the multivariate analysis, there were no significant differences in overall survival (hazard ratio [HR], 1.10; 95% confidence interval [CI], 0.90\u20131.34;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.347), disease\u2010free survival (HR, 1.01; 95% CI, 0.84\u20131.23;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.845), relapse (HR, 0.88; 95% CI, 0.68\u20131.15;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.370), or non\u2010relapse mortality (HR, 1.15; 95% CI, 0.87\u20131.50;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.310) between MSD recipients and UCB recipients. UCB was significantly associated with lower neutrophil (HR, 0.28; 95% CI, 0.24\u20130.33;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and lower platelet (HR, 0.29; 95% CI, 0.23\u20130.36;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) recovery compared to MSD. UCB was significantly associated with a lower incidence of chronic graft\u2010versus\u2010host disease (GVHD) (HR, 0.57; 95% CI, 0.44\u20130.75;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and extensive chronic GVHD (HR, 0.46; 95% CI, 0.32\u20130.67;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) compared to MSD. Similar results were observed after adjusting for differences between MSD and UCB recipients by propensity score matching analysis. Our study demonstrated that single CBT and MSD HCT had similar survival outcomes for adult patients with advanced MDS despite the lower hematopoietic recovery in CBT recipients and higher chronic GVHD in MSD recipients.\n                  <\/jats:p>","DOI":"10.1002\/hon.3217","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:57:26Z","timestamp":1692647846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single\u2010unit unrelated cord blood transplantation versus HLA\u2010matched sibling transplantation in adults with advanced myelodysplastic syndrome: A registry\u2010based study from the adult MDS working group of the Japanese society for transplantation and cellular therapy"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-8463","authenticated-orcid":false,"given":"Takaaki","family":"Konuma","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology The Institute of Medical Science The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-3623","authenticated-orcid":false,"given":"Hidehiro","family":"Itonaga","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Unit Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-9508","authenticated-orcid":false,"given":"Yoshimitsu","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Hematology Kobe City Medical Center General Hospital  Kobe Japan"},{"name":"Department of Environmental Medicine and Population Science Graduate School of Medicine Osaka University  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-8273","authenticated-orcid":false,"given":"Machiko","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Hematology Sasebo City General Hospital  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Aoki","sequence":"additional","affiliation":[{"name":"Stem Cell Genetics Institute for Life and Medical Sciences Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Onizuka","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Tokai University School of Medicine  Isehara 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Anjo Kosei Hospital  Anjo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology Nara Medical University Hospital  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Nakamae","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Hematology National Hospital Organisation Kumamoto Medical Center  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Tsukuba Hospital  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Clinical Precision Research Platform The Institute of Medical Science The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6083","authenticated-orcid":false,"given":"Fumihiko","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kanto\u2010Koshinetsu Block Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Research Institute for Radiation Biology and Medicine Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Atsuta","sequence":"additional","affiliation":[{"name":"Japanese Data Center for Hematopoietic Cell Transplantation  Nagakute Japan"},{"name":"Department of Registry Science for Transplant and Cellular Therapy Aichi Medical University School of Medicine  Nagakute 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