{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:36:04Z","timestamp":1780360564203,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI19\/00925"],"award-info":[{"award-number":["PI19\/00925"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI19\/00887"],"award-info":[{"award-number":["PI19\/00887"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Watchful waiting is an acceptable management strategy for advanced\u2010stage, low tumor burden (LTB) patients with follicular lymphoma (FL). However, the prediction of how long this treatment\u2010free observation period will last remains imperfect. We explored whether total metabolic tumor volume (TMTV) and other positron emission tomography parameters were predictive of time to first treatment (TTFT). We analyzed 97 grade 1\u20133A advanced\u2010stage LTB FL patients and found that a high TMTV was associated with other tumor burden features at diagnosis. Patients with a TMTV above our established cutoff of 50\u00a0mL had a significantly shorter median duration of observation (2.6 vs. 8.8\u00a0years;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001). At 5\u00a0years, 77% of patients with a high TMTV and 46% of patients with a low TMTV required treatment. In the multivariable analysis, a high TMTV was the only independent factor predicting TTFT (hazard ratio\u00a0=\u00a02.09;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.017). Overall, TMTV is a strong predictor of the duration of observation in LTB FL patients. Upon validation of our cutoff in external series and standardization of the methodology, the TMTV could become an additional factor to consider deferring or initiating treatment in otherwise LTB patients.\n                  <\/jats:p>","DOI":"10.1002\/hon.3235","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T05:46:31Z","timestamp":1699508791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A low total metabolic tumor volume independently predicts for a longer time to first treatment in initially observed, low tumor burden follicular lymphoma"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-4971","authenticated-orcid":false,"given":"Pablo","family":"Mozas","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Departament de Medicina, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-5850","authenticated-orcid":false,"given":"Sebastian","family":"Casanueva\u2010Eliceiry","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Serna","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitari Vall d\u2019Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sim\u00f3","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Universitari Vall d\u2019Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rivas\u2010Delgado","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Nadeu","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Gonzalo","family":"Correa","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Pi\u00f1eyroa","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Isabel","family":"P\u00e9rez\u2010Valencia","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Guinetti\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"G\u00f3mez\u2010Hernando","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gin\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Departament de Medicina, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Villamor","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"},{"name":"Hematopathology Unit Department of Pathology Hospital Cl\u00ednic de Barcelona  Barcelona 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Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Departament de Medicina, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid 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Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T11:08:05Z","timestamp":1711451285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/hon.3235"],"URL":"https:\/\/doi.org\/10.1002\/hon.3235","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3235\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3235\/v2\/review1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]},"assertion":[{"value":"2023-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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