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CD19 specific chimeric antigen receptor (CAR) T cell therapy is a game changer that results in durable and complete response rates in almost half of the patients with R\/R DLBCL. Other emerging CD19\u2010targeting therapies include monoclonal antibodies, bispecific antibodies and targeting antibody\u2010drug conjugates, which also show encouraging results. However, the timing and sequencing of different anti\u2010CD19\u2010targeting agents and how they might interfere with subsequent CAR T cell treatment is still unclear. In this review, we summarize the results of the pivotal clinical trials as well as evidence from real\u2010world series of the use of different CD19\u2010targeting approved agents. We discuss the effect of various therapies on CD19 expression and its implications for treatment sequencing.<\/jats:p>","DOI":"10.1002\/hon.3237","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T05:24:06Z","timestamp":1699421046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["How to integrate CD19 specific chimeric antigen receptor T cells with other CD19 targeting agents in diffuse large B\u2010cell lymphoma?"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-9294","authenticated-orcid":false,"given":"Carmen","family":"de Ramon Ortiz","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Oncology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Wang","sequence":"additional","affiliation":[{"name":"Translational Research Center 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