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Since the introduction of combination chemotherapy in the 1960's and radiation dating back to the early 1900's, therapeutic options and by extension, clinical outcomes have improved dramatically with 5\u2010year overall survival (OS) approaching 90% today. [1](#ref\u20100001) Advances in understanding HL biology have additionally facilitated development of targeted agents and immunotherapy which have further improved short and long\u2010term outcomes. Despite continued improvements in up\u2010front and salvage therapy, long\u2010term survivors of HL experience several treatment\u2010associated late toxicities, thus, along with efforts to improve therapeutic efficacy, efforts to reduce late effects remain a high\u2010priority in the field.<\/jats:p>","DOI":"10.1002\/hon.3239","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T05:03:02Z","timestamp":1701406982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Classic Hodgkin lymphoma"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-6754","authenticated-orcid":false,"given":"Justine","family":"Kahn","sequence":"first","affiliation":[{"name":"Columbia University Herbert Irving Comprehensive Cancer Center  New York New York 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