{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:34:28Z","timestamp":1776710068191,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22ym0126041h0002"],"award-info":[{"award-number":["22ym0126041h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["K22K162750"],"award-info":[{"award-number":["K22K162750"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mycosis fungoides (MF) progresses slowly before advancing to skin tumors followed by lymph node and visceral involvement. Among MF progression, stage IIB is an initial time point of tumor formation in MF. Since MF in tumor stage possess abundant blood vessels, it is important to evaluate the pro\u2010angiogenic factors before and after MF in stage IIB. In this report, we investigated pro\u2010angiogenic soluble factors in MF patients, as well as its pro\u2010angiogenetic effects on tumor cells and stroma cells. We first evaluated the serum levels of pro\u2010angiogenic factors in 9 MF patients without tumor formation and 8 MF patients with tumor formation. Among them, the serum MMP\u20109 and plasminogen activator inhibitors 1 (PAI\u20101) was significantly increased in MF with tumor formation compared in MF without tumor formation, leading to favorable formation of human dermal microvascular endothelial cells tube networks. Moreover, PAI\u20101 stimulation significantly increased the mRNA expression and protein production MMP\u20109 on monocytes derived M2 macrophages and HUT\u201078. Furthermore, since MMP\u20109 production from tumor cells as well as stromal cells is suppressed by bexarotene, we evaluate the baseline serum pro\u2010angiogenic factors including MMP\u20109 in 16 patients with advanced cutaneous T cell lymphoma treated with bexarotene. The serum levels of MMP\u20102 and MMP\u20109 was significantly increased in bexarotene non\u2010responded patients compared to responded patients. Our present study suggested the significance of MMP\u20109 and PAI\u20101 for the progression of MF stage toward to the tumor stage, and could be a therapeutic target in future.<\/jats:p>","DOI":"10.1002\/hon.3244","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T04:49:03Z","timestamp":1704430143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Possible effects of plasminogen activator inhibitor\u20101 on promoting angiogenesis through matrix metalloproteinase 9 in advanced mycosis fungoides"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai 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