{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:30:46Z","timestamp":1782217846856,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although chronic lymphocytic leukemia (CLL) predominantly affects the elderly, limited data exists about the outcomes of over 80\u2010year\u2010old patients, usually underrepresented in clinical trials. We conducted a multicenter study enrolling 79 consecutive CLL patients \u226580\u00a0years at the time of frontline therapy, all treated with ibrutinib. Nearly 48% of cases exhibited unmutated\n                    <jats:italic>IGHV<\/jats:italic>\n                    genes, 32% 17p deletion, and 39.2%\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations; 63.3% displayed a cumulative illness rating scale (CIRS)\u00a0&gt;\u00a06. The overall response rate on ibrutinib, computed in 74\/79 patients (5 patients excluded for early withdrawal), was 89.9%. After a median follow\u2010up of 28.9\u00a0months, the median progression\u2010free survival (PFS) and overall survival (OS) were 42.5 and 51.8\u00a0months, respectively. CIRS&gt;6 and temporary discontinuation of ibrutinib lasting for 7\u201330\u00a0days were the only parameters associated with a significantly shorter PFS and were both relevant in predicting a shorter PFS compared to patients with CIRS\u22646 and therapy discontinuation \u22647\u00a0days. The most common grade\u22653 adverse events were infections (25.5%), neutropenia (10.1%), and anemia (2.5%). Eighteen patients (22.8%) experienced a cardiovascular event, including grade\u20102 atrial fibrillation (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a09; 11%), grade\u20102 hypertension (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05; 6%), heart failure (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03; 3%), and acute coronary syndrome (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01; 1%). Mild bleeding events were observed in 27 patients (34.2%). Ibrutinib was permanently discontinued in 26 patients due to progressive disease (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011, including 5 Richter's syndromes), secondary malignancies (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06), infections (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03), cardiac failure (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03), severe bleeding (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a02), and sudden death (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01). In conclusion, our analyses confirmed the overall effectiveness and favorable safety profile of the ibrutinib\u2010single agent therapeutic approach in CLL patients \u226580\u00a0years.\n                  <\/jats:p>","DOI":"10.1002\/hon.3249","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T14:59:05Z","timestamp":1706108345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ibrutinib as first line therapy in chronic lymphocytic leukemia patients over 80\u00a0years old: A retrospective real\u2010life multicenter Italian cohort"],"prefix":"10.1002","volume":"42","author":[{"given":"Enrica Antonia","family":"Martino","sequence":"first","affiliation":[{"name":"Hematology Unit AO Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-9474","authenticated-orcid":false,"given":"Francesca Romana","family":"Mauro","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine 'Sapienza' University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Reda","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-1396","authenticated-orcid":false,"given":"Luca","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Radiologiche ed Ematologiche Divisione di Ematologia Fondazione Policlinico universitario A Gemelli  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-7200","authenticated-orcid":false,"given":"Andrea","family":"Visentin","sequence":"additional","affiliation":[{"name":"Hematology and Clinical Immunology Unit Department of Medicine University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-7901","authenticated-orcid":false,"given":"Annamaria","family":"Frustaci","sequence":"additional","affiliation":[{"name":"Department of Haematology Niguarda Cancer Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Vigna","sequence":"additional","affiliation":[{"name":"Hematology Unit AO Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pepe","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine 'Sapienza' University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioacchino","family":"Catania","sequence":"additional","affiliation":[{"name":"A.O.N. 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