{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:07:46Z","timestamp":1772125666279,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphoma (MCL) is an uncommon and incurable B\u2010cell lymphoma subtype that has an aggressive course. Hepatitis B virus (HBV) infection has been associated with an increased risk for B\u2010cell lymphomas, and is characterized by distinct clinical and genetic features. Here, we showed that 9.5% of MCL Chinese patients were hepatitis B surface antigen positive (HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    ). Compared to HBsAg\u2010negative (HBsAg\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) patients, HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    MCL patients had a greater incidence of elevated lactate dehydrogenase (LDH), but no difference was observed in the other clinical characteristics, including sex, age, ECOG ps, Ann Arbor stage, MIPI, extranodal involvement and Ki\u201067. The HD\u2010AraC (high\u2010dose cytarabine) regimen was the main first\u2010line induction regimen for younger HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    patients, and cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) were used for elderly patients. HBsAg seropositivity was associated with a significantly shorter PFS than HBsAg seronegativity when patients were treated with rituximab or CHOP\u2010based regimens. Compared with CHOP, the HD\u2010AraC regimen was associated with longer PFS in HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    patients. Treatment with a Bruton tyrosine kinase inhibitor (BTKi) alone can also cause HBV reactivation. Among the 74 patients who underwent targeted deep sequencing (TDS), the nonsynonymous mutation load of HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    MCL patients was greater than that of HBsAg\n                    <jats:sup>\u2212<\/jats:sup>\n                    MCL patients. HDAC1, TRAF5, FGFR4, SMAD2, JAK3, SMC1A, ZAP70, BLM, CDK12, PLCG2, SMO, TP63, NF1, PTPR, EPHA2, RPTOR and FIP1L1 were significantly enriched in HBsAg\n                    <jats:sup>+<\/jats:sup>\n                    MCL patients.\n                  <\/jats:p>","DOI":"10.1002\/hon.3268","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T03:58:17Z","timestamp":1714190297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment patterns, clinical outcomes and gene mutation characteristics of hepatitis B virus\u2010associated mantle cell lymphoma"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5005-9366","authenticated-orcid":false,"given":"Jiangfang","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"},{"name":"Department of Hematology The Second People's Hospital of Jincheng City  Jincheng Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"},{"name":"Department of Oncology The Affiliated Hospital Inner Mongolia Medical University  Hohhot Inner Mongolia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangrui","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology Daping Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehui","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haige","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology Department of Internal Medicine Xijing Hospital Air Force Medical University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Lymphoma &amp; Hematology Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.12.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010014\u20100084\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12892"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.06.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201006\u2010275818"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"18","article-title":"The association of hepatitis B virus infection with B\u2010cell non\u2010Hodgkin lymphoma \u2010 a review","volume":"2","author":"Marcucci F","year":"2012","journal-title":"Am J Blood Res"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(22)00124\u20108"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.08.048"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21701"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201011\u2010817601"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006410"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.103038"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2860"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15643"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201006\u2010095331"},{"key":"e_1_2_10_18_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) B\u2010Cell Lymphomas\/Mantle Cell Lymphoma. 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