{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:59:23Z","timestamp":1783688363377,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ELOQUENT\u20103 trial demonstrated the superiority of the combination of elotuzumab, pomalidomide, and dexamethasone (EloPd) in terms of efficacy and safety, compared to Pd in relapsed\/refractory multiple myeloma (RRMM), who had received at least two prior therapies, including lenalidomide and a proteasome inhibitor. The present study is an 18\u2010month follow\u2010up update of a previously published Italian real\u2010life RRMM cohort of patients treated with EloPd. This revised analysis entered 319 RRMM patients accrued in 41 Italian centers. After a median follow\u2010up of 17.7\u00a0months, 213 patients (66.4%) experienced disease progression or died. Median progression\u2010free survival (PFS) and overall survival (OS) were 7.5 and 19.2\u00a0months, respectively. The updated multivariate analysis showed a significant reduction of PFS benefit magnitude both in advanced International Staging System (ISS) (II and III) stages and previous exposure to daratumumab cases. Instead, advanced ISS (II and III) stages and more than 2 previous lines of therapy maintained an independent prognostic impact on OS. Major adverse events included grade three\u2010fourths neutropenia (24.9%), anemia (13.4%), lymphocytopenia (15.5%), and thrombocytopenia (10.7%), while infection rates and pneumonia were 19.3% and 8.7%, respectively. A slight increase in the incidence of neutropenia and lymphocytopenia was registered with longer follow\u2010up. In conclusion, our real\u2010world study still confirms that EloPd is a safe and possible therapeutic choice for RRMM. Nevertheless, novel strategies are desirable for those patients exposed to daratumumab.<\/jats:p>","DOI":"10.1002\/hon.3290","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T07:27:37Z","timestamp":1717140457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Elotuzumab plus pomalidomide and dexamethasone in relapsed\/refractory multiple myeloma: Extended follow\u2010up of a multicenter, retrospective real\u2010world experience with 321 cases outside of controlled clinical trials"],"prefix":"10.1002","volume":"42","author":[{"given":"Enrica Antonia","family":"Martino","sequence":"first","affiliation":[{"name":"Department of Onco\u2010hematology Hematology Unit Azienda Ospedaliera Annunziata  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-4147","authenticated-orcid":false,"given":"Salvatore","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Hematology Unit, Ospedale Cardarelli  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Galli","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit ASST Papa Giovanni  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Derudas","sequence":"additional","affiliation":[{"name":"Department of Hematology Businco Hospital  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mina","sequence":"additional","affiliation":[{"name":"Division of Hematology AOU Citt\u00e0 della Salute e della Scienza di Torino University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-231X","authenticated-orcid":false,"given":"Roberta","family":"Della Pepa","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Hematology Unit University of Naples \"Federico II\"  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Zambello","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova Hematology Unit  Padova Italy"},{"name":"Veneto Institute of Molecular Medicine  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Vigna","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010hematology Hematology Unit Azienda Ospedaliera Annunziata  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-2404","authenticated-orcid":false,"given":"Antonella","family":"Bruzzese","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010hematology Hematology Unit Azienda Ospedaliera Annunziata  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mangiacavalli","sequence":"additional","affiliation":[{"name":"Division of Hematology IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zamagni","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \"Ser\u00e0gnoli\"  Bologna Italy"},{"name":"Dipartimento di Scienze Mediche e Chirurgiche Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catello","family":"Califano","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology Unit \"A. Tortora\" Hospital  Pagani Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Musso","sequence":"additional","affiliation":[{"name":"Department of Oncology Onco\u2010Hematology Unit and TMO U.O.C.  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Conticello","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Policlinico\u2010S. Marco University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cerchione","sequence":"additional","affiliation":[{"name":"Hematology Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-8618","authenticated-orcid":false,"given":"Giuseppe","family":"Mele","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Perrino  Brindisi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Di Renzo","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Vito Fazzi  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-7347","authenticated-orcid":false,"given":"Massimo","family":"Offidani","sequence":"additional","affiliation":[{"name":"Hematology Unit AOU delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8635-6902","authenticated-orcid":false,"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Hematology Unit \"Dimiccoli\" Hospital  Barletta (BAT) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Margiotta","family":"Casaluci","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Translational Medicine University of Eastern Piedmont  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Rago","sequence":"additional","affiliation":[{"name":"UOSD Ematologia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1515-0090","authenticated-orcid":false,"given":"Roberto","family":"Ria","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe\u2010J) University of Bari Aldo Moro Medical School Internal Medicine \u201cG. Baccelli\u201d; CITEL  Bari Italy"},{"name":"Interdepartmental Centre for Research in Telemedicine University of Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Uccello","sequence":"additional","affiliation":[{"name":"Hematology Department G. Garibaldi Hospital  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3430-6115","authenticated-orcid":false,"given":"Gregorio","family":"Baril\u00e0","sequence":"additional","affiliation":[{"name":"Hematology Unit Ospedale San Bortolo  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital University Riuniti  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-2082","authenticated-orcid":false,"given":"Loredana","family":"Pettine","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-698X","authenticated-orcid":false,"given":"Iolanda Donatella","family":"Vincelli","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology and Radiotherapy Hematology Unit Great Metropolitan Hospital \"Bianchi\u2010Melacrino\u2010Morelli\"  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Brunori","sequence":"additional","affiliation":[{"name":"Internal Medicine Ospedale Santa Croce  Fano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-2822","authenticated-orcid":false,"given":"Fabrizio","family":"Accardi","sequence":"additional","affiliation":[{"name":"Department of Hematology I Azienda Ospedaliera Ospedali Riuniti Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Amico","sequence":"additional","affiliation":[{"name":"UOSD Ematologia, AORN San Pio  Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Amendola","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Ospedaliera Regionale \"San Carlo\"  Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Fontana","sequence":"additional","affiliation":[{"name":"Hematology and Transplant Center University Hospital \"San Giovanni di Dio e Ruggi d'Aragona\"  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velia","family":"Bongarzoni","sequence":"additional","affiliation":[{"name":"Department of Hematology San Giovanni\u2010Addolorata Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Rossini","sequence":"additional","affiliation":[{"name":"Hematology and Cell Therapy Unit IRCCS Istituto Tumori \"Giovanni Paolo II\" Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Cotzia","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010 Ospedale E. Muscatello\u2010Augusta  Siracusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gozzetti","sequence":"additional","affiliation":[{"name":"Hematology Azienda Ospedaliera Universitaria Senese University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Unit of Hematology and Stem Cell Transplantation AOUC Policlinico Bari  Bari Italy"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area \"Aldo Moro\" University School of Medicine  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Sgherza","sequence":"additional","affiliation":[{"name":"Unit of Hematology and Stem Cell Transplantation AOUC Policlinico Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Reddiconto","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Vito Fazzi  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Maroccia","sequence":"additional","affiliation":[{"name":"Hematology Unit \u2010 Ospedale dell'Angelo Azienda ULSS n.3 Serenissima  Venezia Mestre Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Lymphoproliferative Diseases Unit Tor Vergata University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3785-9824","authenticated-orcid":false,"given":"Giuseppe","family":"Bertuglia","sequence":"additional","affiliation":[{"name":"Dipartimento di Oncologia ed Ematologia SC Ematologia 1 A.O. Citta' della Salute e della Scienza di Torino P.O. Molinette  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Nappi","sequence":"additional","affiliation":[{"name":"Hematology Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-6608","authenticated-orcid":false,"given":"Emiliano","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Gamberi","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Hematology Azienda Policlinico Umberto I Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di Raimondo","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Policlinico\u2010S. Marco University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Neri","sequence":"additional","affiliation":[{"name":"Scientific Directorate Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Morabito","sequence":"additional","affiliation":[{"name":"Gruppo Amici Dell'Ematologia Foundation\u2010GrADE  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellegrino","family":"Musto","sequence":"additional","affiliation":[{"name":"Unit of Hematology and Stem Cell Transplantation AOUC Policlinico Bari  Bari Italy"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area \"Aldo Moro\" University School of Medicine  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010hematology Hematology Unit Azienda Ospedaliera Annunziata  Cosenza Italy"},{"name":"Department of Pharmacy Health and Nutritional Science University of Calabria  Rende Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.313"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201010\u2010116129"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.11.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32065"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2022.2145882"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.100616"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010013\u20101493\u20108"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201007\u20104246"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010014\u20101610\u20103"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31680"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.241513"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3031"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13723"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.890376"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.119"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1274973"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.02815"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.283251"},{"key":"e_1_2_10_20_1","unstructured":"European Medicines.Agency Empliciti INN\u2010Elotuzumab. Accessed on 20 January 2024.https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/emplicitiepar\u2010product\u2010information_it.pdf"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404284"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201010\u2010299487"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21771"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14121"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2023.2218543"},{"key":"e_1_2_10_26_1","article-title":"Genomic and immune determinants of resistance to anti\u2010CD38 monoclonal antibody\u2010based therapy in relapsed refractory multiple myeloma","author":"Ziccheddu B","year":"2023","journal-title":"medRxiv"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.247"},{"key":"e_1_2_10_28_1","unstructured":"A Study of Iberdomide (CC\u2010220) in Combination with Elotuzumab and Dexamethasone for Relapsed\/Refractory Multiple Myeloma (CC\u2010220). ClinicalTrials.Gov Identifier: NCT 05560399."},{"key":"e_1_2_10_29_1","unstructured":"IsatuximabP.Elotuzumab and Dexamethasone in Relapsed And\/or Refractory Multiple Myeloma (IMPEDE). ClinicalTrials.Gov Identifier: NCT 04835129."},{"key":"e_1_2_10_30_1","unstructured":"Novel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma ClinicalTrials.Gov Identifier: NCT 05002816."}],"updated-by":[{"DOI":"10.1002\/hon.70039","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000}}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T04:27:31Z","timestamp":1755750451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/hon.3290"],"URL":"https:\/\/doi.org\/10.1002\/hon.3290","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]},"assertion":[{"value":"2024-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3290"}}