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However, randomized trials are lacking to determine the best strategy for intensification. We report on A\u2010AVD escalation treatment outcomes for 15 iPET\u2010positive patients post\u2010ABVD. Overall response and complete response rates were 80% and 60%, respectively. Four patients underwent salvage therapy followed by autologous stem cell transplantation. At a median 17\u2010month follow\u2010up, all patients are alive, 87% in complete remission, and 1\u2010year PFS was 57.8%. For patients ineligible for BEACOPP due to age, comorbidities, or preference, A\u2010AVD escalation may be a viable alternative.<\/jats:p>","DOI":"10.1002\/hon.3299","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:27:57Z","timestamp":1723451277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of escalating therapy with brentuximab vedotin\u2010AVD in advanced stage Hodgkin lymphoma patients with positive interim positron emission tomography after ABVD"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-7306","authenticated-orcid":false,"given":"Carmen","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Hematology Department Institute of Cancer and Blood Diseases (ICAMS) Hospital Cl\u00ednic of Barcelona  Barcelona Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute\u2013IDIBAPS  Barcelona 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