{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:38Z","timestamp":1772118578952,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The overall prognosis of older patients with acute myeloid leukemia (AML) is dismal. Only a small subgroup experiences long\u2010term survival. The discrimination between patients who are candidates for potentially curative approaches and those who are not is crucial since \u2010 in addition to differences in terms of AML\u2010directed treatment \u2010 different policies concerning intensive care unit (ICU) admission and involvement of specialized palliative care (SPC) seem obvious. To shed more light on characteristics, outcomes and health care utilization of older individuals with AML, we conducted an analysis comprising 107 consecutive patients with newly diagnosed AML aged \u226570\u00a0years treated at an academic tertiary care center in Germany between 1 January 2015, and 31 December 2020. Median age was 75\u00a0years (range: 70\u201387\u00a0years); 45% of patients were female. The proportion of patients receiving intensive induction chemotherapy was 35%, 55% had low\u2010intensity treatment and 10% did not receive AML\u2010directed treatment or follow\u2010up ended before treatment initiation. At least one ICU admission was documented for 47% of patients; SPC was involved in 43% of cases. Median follow\u2010up was 199\u00a0days. The median overall survival (OS) was 2.5\u00a0months; the 1\u2010year OS rate was 16%. Among patients who died during observation, the median proportion of time spent in the hospital between AML diagnosis and death was 56%. The most common places of death were normal wards (31%) and the ICU (28%). Patients less frequently died in a palliative care unit (14%) or at home (12%). In summary, results of the present analysis confirm the unfavorable prognosis of older patients with AML despite intensive health care utilization. Future efforts in this patient group should aim at optimizing the balance between appropriate AML\u2010directed treatment on the one hand and health care utilization including ICU stays on the other hand.<\/jats:p>","DOI":"10.1002\/hon.3300","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T01:25:36Z","timestamp":1723598736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics, outcomes and health care utilization of patients with acute myeloid leukemia aged 70\u00a0years or older: A single\u2010center retrospective analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-6110","authenticated-orcid":false,"given":"Marie Anne\u2010Catherine","family":"Neumann","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Hendrik","family":"Naendrup","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garcia Borrega","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismini","family":"Halmer","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Altenrath","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle","family":"Sieg","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-3514","authenticated-orcid":false,"given":"Dennis A.","family":"Eichenauer","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-8504","authenticated-orcid":false,"given":"Jan\u2010Michel","family":"Heger","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) University of Cologne Faculty of Medicine and University Hospital of Cologne  Cologne Germany"},{"name":"Mildred Scheel School of Oncology Aachen Bonn Cologne D\u00fcsseldorf (MSSO ABCD) Faculty of Medicine and University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.04.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010017\u20103150\u20103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33458"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009632"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010023\u201002134\u2010w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010023\u201002027\u2010y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010022\u201000700\u2010x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2021.0249"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29430"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201007\u2010235358"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201008\u2010733196"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010023\u201000835\u20105"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.7149"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2020.11.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32397"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010024\u201007349\u2010z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010018\u20105339\u2010x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.6343"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010014\u20102333\u2010x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010019\u201003748\u20101"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/pmr.2022.0056"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T11:31:42Z","timestamp":1727263902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/hon.3300"],"URL":"https:\/\/doi.org\/10.1002\/hon.3300","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3300\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3300\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3300\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3300\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3300\/v1\/review1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"2024-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3300"}}