{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:11:44Z","timestamp":1781525504818,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To retrospectively analyze whether the second revision of the international staging system (R2\u2010ISS) influenced prognosis at treatment initiation in patients with multiple myeloma (MM) receiving anti\u2010CD38 antibody\u2010based triplet treatments. High\u2010risk chromosomal abnormalities were examined from diagnosis to treatment initiation and considered positive if detected once. R2\u2010ISS was recalculated at the initiation of treatment and defined as \u201cdynamic R2\u2010ISS.\" Data from 150 patients who underwent the defined treatments were analyzed. The median progression\u2010free survival (PFS) was 19.5\u00a0months, and the median overall survival (OS) was 36.5\u00a0months. Dynamic R2\u2010ISS significantly stratified prognoses for both PFS and OS. The median PFS for patients with dynamic R2\u2010ISS IV was 3.3\u00a0months, and the median OS was 11.7\u00a0months, indicating extremely poor outcomes. Although the Revised International Staging System (R\u2010ISS) calculated at the initiation of treatment significantly stratified treatment outcomes, the patients classified as R\u2010ISS could be further stratified by R2\u2010ISS to provide better prognostic information. Dynamic R2\u2010ISS showed potential as a prognostic tool in patients with MM who are treated with anti\u2010CD38 antibody\u2010based triplet therapies.<\/jats:p>","DOI":"10.1002\/hon.3302","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T09:08:16Z","timestamp":1722676096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic value of the \u201cdynamic\u201d R2\u2010ISS in patients with multiple myeloma undergoing anti\u2010CD38 antibody\u2010based triplet therapies"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-7756","authenticated-orcid":false,"given":"Taku","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Hematology Japanese Red Cross Medical Center  Tokyo 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