{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:04:07Z","timestamp":1788627847314,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Involvement of female genital track (FGT) by diffuse large B cell lymphoma (DLBCL) represents an extremely rare diagnosis. Especially data regarding early\u2010stage disease (i.e., IE, IIE) is very limited. Importantly, previous studies showed controversial results about the risk of central nervous system (CNS) relapse in this entity. Herein, we describe one of the largest reported real\u2010world series of patients with early\u2010stage FGT DLBCL aiming to investigate the clinicopathological characteristics, response to therapy and survival outcomes in the era of immunochemotherapy. We analyzed 21 consecutive patients with biopsy proven DLBCL from uterus or ovary classified as stage IE or IIE out of 1905 newly diagnosed DLBCL patients (1.1%). Uterine and ovarian localization was observed in 14 and seven patients, respectively. Median age was 66\u00a0years (range 33\u201396); 9\/21 (43%) were &lt;55\u00a0years. Regarding Cell of Origin DLBCL subtype, Germinal Center B\u2010cell subtype was found in seven patients, non\u2010GCB in 10 and non\u2010classified in 4 patients. Median follow\u2010up was 57\u00a0months and 5\u2010year overall survival, lymphoma specific survival and Freedom from Progression were 78%, 89% and 90%, respectively. There was no correlation of patients' characteristics with survival parameters. Interestingly, none of the patients experienced CNS relapse. Our results indicate that localized FGT DLBCL exhibits a good prognosis and may not increase the risk for secondary CNS involvement.<\/jats:p>","DOI":"10.1002\/hon.3303","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:59:27Z","timestamp":1722934767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics and outcome of early\u2010stage diffuse large B cell lymphoma of female genital track: A retrospective study of the Hellenic cooperative lymphoma group"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-3351","authenticated-orcid":false,"given":"Evgenia","family":"Verrou","sequence":"first","affiliation":[{"name":"Department of Hematology Theagenion Cancer Hospital  Thessaloniki 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chara","family":"Giatra","sequence":"additional","affiliation":[{"name":"Department of Hematology and Lymphoma Evangelismos General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Banti","sequence":"additional","affiliation":[{"name":"Department of Hematology Papageorgiou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Kyriakidis","sequence":"additional","affiliation":[{"name":"Department of Hematology Aghios Savvas Cancer Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionisios","family":"Stoumpos","sequence":"additional","affiliation":[{"name":"Department of Hematology Metaxa Cancer Hospital  Piraeus 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