{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:35:41Z","timestamp":1790908541326,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lombardy represents the largest region of Italy by population, with almost 10 million residents, a dimension similar to a medium size country like Sweden or Belgium. The CML subcommittee of the Lombardy Hematology Network (REL\u2010CML) conducted a study at the beginning of 2023. Prevalence was calculated by direct input from the 21 centers participating in REL\u2010CML. Tyrosine Kinase Inhibitors (TKI) prescription records collected from the ARIA regional registry were used to estimate the number of CML patients followed in smaller centers not participating in REL\u2010CML. A total of 2285 patients were registered, representing a prevalence of 0.23 \u2030. These data were compared to a similar census conducted in 2005, at the beginning of the TKI era, where a prevalence of 0.029\u2030 was calculated. This indicates that an almost 10 times increase took place during this period of time. Imatinib represents the most frequently prescribed first\u2010line TKI; its use in 2022 still represented 75% of total first line prescriptions. An increased concentration of the care of CML patients in specialized REL centers with a decreased dispersion of patients in small centers was also evident over this 18\u00a0year period of time. Nineteen % of patients discontinued treatment, highlighting persisting logistical and biological challenges; one some recommendations on CML management are included to this aim.<\/jats:p>","DOI":"10.1002\/hon.3311","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T12:29:54Z","timestamp":1726921794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Direct determination of chronic myeloid leukemia prevalence in Lombardy\u2014Italy: Global implications"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-9697","authenticated-orcid":false,"given":"N.","family":"Polverelli","sequence":"first","affiliation":[{"name":"Unit of Blood Diseases and Stem Cell Transplantation ASST Spedali Civili  Brescia Italy"},{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Anghilieri","sequence":"additional","affiliation":[{"name":"Oncology Department ASST Lecco  Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Elena","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Intermesoli","sequence":"additional","affiliation":[{"name":"Unit of Hematology ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pungolino","sequence":"additional","affiliation":[{"name":"Unit of Hematology ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"D\u2019Adda","sequence":"additional","affiliation":[{"name":"Hematology Unit ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-0812","authenticated-orcid":false,"given":"A.","family":"Iurlo","sequence":"additional","affiliation":[{"name":"Unit of Hematology Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maffioli","sequence":"additional","affiliation":[{"name":"Unit of Hematology ASST Sette Laghi  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lunghi","sequence":"additional","affiliation":[{"name":"Unit of Hematology and Bone Marrow Transplantation IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bertolli","sequence":"additional","affiliation":[{"name":"Hematology Unit ASST Valle Olona  Busto Arsizio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Orofino","sequence":"additional","affiliation":[{"name":"Division of Hematology ASST Ovest Milanese  Legnano\u2010Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sissa","sequence":"additional","affiliation":[{"name":"Unit of Hematology ASST Mantova  Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fiamenghi","sequence":"additional","affiliation":[{"name":"Unit of Hematology ASST Cremona  Cremona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gardellini","sequence":"additional","affiliation":[{"name":"Unit of Hematology ASST Valduce  Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ubezio","sequence":"additional","affiliation":[{"name":"Unit of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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