{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:04:39Z","timestamp":1784664279151,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Primary lymphoma of the female genital tract (PLFGT) is a rare type of extranodal lymphoma. In this retrospective study from the International Extranodal Lymphoma Study Group, we analyzed clinical data from 60 women diagnosed with PLFGT between 1982 and 2012. The median age was 52\u00a0years. Limited stage, as defined by the Ann Arbor and FIGO staging systems, was observed in 55% and 63% of cases, respectively. The uterus was the primary site of lymphoma in 25 cases, with the ovaries as the second most common site (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a024). The most common histological subtype was diffuse large B\u2010cell lymphoma (DLBCL,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a044), followed by follicular lymphoma and marginal zone lymphoma (6 patients each). Two patients received surgery alone as first\u2010line therapy, while 58 underwent systemic therapy, 16 following major surgery. Thirteen patients received consolidation radiotherapy and six were given central nervous system (CNS) prophylaxis. Twenty patients had disease progression or recurrence. Six patients with DLBCL (14%) experienced CNS relapse, which was the only site of recurrence in five of them. All but one patient with CNS relapse had primary ovarian involvement, and three had bulky disease; none of these patients had received CNS prophylaxis. With a median follow\u2010up of 60\u00a0months, the median overall survival of the DLBCL cohort was approximately 13\u00a0years, with a 5\u2010year survival rate of 77%. In multivariable analysis, advanced disease according to the FIGO system was the only parameter significantly associated with shorter overall, cause\u2010specific, and progression\u2010free survival in patients with DLBCL.\n                  <\/jats:p>","DOI":"10.1002\/hon.3312","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T15:29:07Z","timestamp":1727364547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Superior prognostic accuracy of FIGO staging system in primary female genital tract lymphomas: A retrospective study (IELSG35)"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-9835","authenticated-orcid":false,"given":"Maria Cristina","family":"Pirosa","sequence":"first","affiliation":[{"name":"Oncology Institute of Southern Switzerland Ente Ospedaliero Cantonale  Bellinzona Switzerland"},{"name":"Institute of Oncology Research  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Abdullah Center for Oncology and Liver Disease  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Gardella","sequence":"additional","affiliation":[{"name":"Institut Catala d'Oncologia  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Bairey","sequence":"additional","affiliation":[{"name":"Davidoff Cancer Center Rabin Medical Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Pavlovsky","sequence":"additional","affiliation":[{"name":"Fundaleu\u2010Fundaci\u00f3n Para Combatir la Leucemia  Buenos Aires Argentina"},{"name":"Centro de Hematologia Pavlovsky  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Stathis","sequence":"additional","affiliation":[{"name":"Oncology Institute of Southern Switzerland Ente Ospedaliero Cantonale  Bellinzona Switzerland"},{"name":"Faculty 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