{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:12:01Z","timestamp":1792293121642,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) provides durable remission for patients with adult T\u2010cell leukemia\/lymphoma (ATL); however, few studies have focused on post\u2010transplant outcomes in ATL patients \u226449\u00a0years. To clarify prognostic factors in ATL among patients &lt;40\u00a0years (adolescents and young adult [AYA];\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a073) and 40\u201349\u00a0years (Young;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0330), we conducted a nationwide retrospective study. Estimated 3\u2010year overall survival (OS) rates were 61.8% and 43.1% in AYA and Young patients, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.005). In the multivariate analysis, Young patients showed worse OS (Hazard ratio (HR) [95% confidential interval] 1.62 [1.10\u20132.39],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.015), chronic graft\u2010versus\u2010host disease (GVHD)\u2010free and relapse\u2010free survival (CRFS) (HR 1.54 [1.10\u20132.14],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.011), and GVHD\u2010free and relapse\u2010free survival (GRFS) (HR 1.40 [1.04\u20131.88],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.026) than AYA patients. No significant differences were observed in OS, CRFS, or GRFS between the myeloablative conditioning (MAC) and reduced\u2010intensity conditioning (RIC) regimens; however, non\u2010relapse mortality was significantly lower in patients with the RIC regimen than those with the MAC regimen (HR 0.46 [0.24\u20130.86],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.015). In summary, OS was worse in Young patients than in AYA patients in the allo\u2010HSCT setting for ATL. Furthermore, the RIC regimen has potential as an alternative treatment option for ATL patients \u226449\u00a0years.\n                  <\/jats:p>","DOI":"10.1002\/hon.3315","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:06:48Z","timestamp":1728086808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Allogeneic transplantation for adult T\u2010cell leukemia\/lymphoma in adolescent and young adults and young patients: A nationwide retrospective study by the ATL working group of the Japan society for transplantation and cellular therapy"],"prefix":"10.1002","volume":"42","author":[{"given":"Hidehiro","family":"Itonaga","sequence":"first","affiliation":[{"name":"Transfusion and Cell Therapy Unit Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Laboratory of Hematoimmunology Graduate School of Health Sciences University of the Ryukyus  Nishihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura General Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeharu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Hematology Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Hematology Hamanomachi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Mori","sequence":"additional","affiliation":[{"name":"Hematology Oncology &amp; Cardiovascular Medicine Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Hematology National Hospital Organization Kumamoto Medical Center  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Hematology Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-8273","authenticated-orcid":false,"given":"Machiko","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Hematology Sasebo City General Hospital  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Nakamae","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Hematology Oita University Hospital  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Morishima","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology Second Department of Medicine Graduate School of Medicine University of the Ryukyus Hospital  Nishihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4866-9307","authenticated-orcid":false,"given":"Yoshinobu","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Atsuta","sequence":"additional","affiliation":[{"name":"Japanese Data Center for Hematopoietic Cell Transplantation  Nagakute Japan"},{"name":"Department of Registry Science for Transplant and Cellular Therapy Aichi Medical University School of Medicine  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Fuji","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka International Cancer Center Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoshimitsu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology Kagoshima University Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v50.3.481.481"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2534"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.18.00501"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.1991.tb08051.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201009\u2010242347"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2007.11.9958"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.37.3472"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13338"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.67.7732"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)32984\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15431"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016862"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403682"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201010\u2010247510"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.143"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201007\u2010444372"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.308"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13398"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14658"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15097"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.01.011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25438"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201003\u2010414490"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004932"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010013\u20101307\u2010y"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.012"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.07.010"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2276058"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010018\u20100400\u20105"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001445\u20100"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010023\u201001969\u20107"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010015\u20101894\u2010x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010015\u20101907\u20109"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf03006932"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.12.497"},{"issue":"6","key":"e_1_2_9_39_1","first-page":"825","article-title":"1994 consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"e_1_2_9_40_1","first-page":"250","article-title":"Chronic graft\u2010versus\u2010host disease and other late complications of bone marrow transplantation","volume":"28","author":"Sullivan KM","year":"1991","journal-title":"Semin Hematol"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201010\u2010609032"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.00396"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018030171"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100258(19990330)18:6<695::aid\u2010sim60>3.3.co;2\u2010f"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.2307\/2670170"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.10.031"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.05.009"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.04.014"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001324\u20108"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2020.12.013"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010016\u20102736\u20105"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1532\/ijh97.07070"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.010"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.92"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201011\u20104193"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.11.005"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.02.014"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.38.2101"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12962"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201001\u2010761874"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.3315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T04:51:45Z","timestamp":1734411105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.3315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/hon.3315"],"URL":"https:\/\/doi.org\/10.1002\/hon.3315","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.3315\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3315\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3315\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3315\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.3315\/v1\/review1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"assertion":[{"value":"2024-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3315"}}