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Leukemic cells were classified according to the French\u2013American\u2013British classification. M4 AML cells from two patients produced some O upon stimulation with opsonized zymosan (OZ), phorbol myristate acetate (PMA) or N\u2010formyl\u2010methionyl\u2010leucyl\u2010phenylalanine (FMLP), but less than normal granulocytes or monocytes. M5b AML cells from one patient produced as much O in response to these stimulants as normal monocytes. No O generation was induced in other types of leukemic cells. Total SOD activity in AML cells was significantly greater in normal granulocytes, but was only half of the activity in ALL cells. Mn\u2010SOD in AML cells was very low or undetectable. These results suggest that except in M5b cells, decreased O production may contribute to susceptibility to infections in AML patients. Decreased Mn\u2010SOD activity in AML cells may predispose them to oxidative stress. Copyright \u00a9 2002 John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.699","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T23:07:57Z","timestamp":1048028877000},"page":"11-16","source":"Crossref","is-referenced-by-count":20,"title":["Superoxide radical generation and Mn\u2010 and Cu\u2010Zn superoxide dismutases activities in human leukemic cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Masahiko","family":"Kato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Kuroiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihisa","family":"Kozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,31]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.000525"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35030140"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/43459"},{"key":"e_1_2_1_5_2","first-page":"1141","article-title":"Role of superoxide dismutase in cancer: a review","volume":"39","author":"Oberley LW","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_2","first-page":"2962","article-title":"Copper\u2010 and zinc\u2010containing superoxide dismutase and manganese\u2010containing superoxide dismutase in human tissues and human malignant tumors","volume":"41","author":"Westman NG","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80268-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2000.104"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107236"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(90)90457-K"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00276-9"},{"key":"e_1_2_1_12_2","first-page":"13","article-title":"Superoxide production by neutrophils in children with malignant tumors treated with recombinant human granulocyte colony\u2010stimulating factor","volume":"80","author":"Iacobini M","year":"1995","journal-title":"Haematologica"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80949-9"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(89)90164-2"},{"key":"e_1_2_1_15_2","first-page":"227","volume-title":"Methods in Enzymology","author":"Nakano M","year":"1990"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.2000.0513"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-620"},{"key":"e_1_2_1_18_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood. 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